ReviewAnnals of medicine2025
The multiple functions of CD5 in diseases related to immune disorders.
Review in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- [Bidirectional two-sample MR analysis of causal relationships between human inflammatory proteins and HS and keloids].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Article
- Removal of CD5 on T cells alters their differentiation and cytokine production in anFrontiers in immunology · 2026Article
- Targeted proteomics identifies differentially expressed proteins in Sjögren's disease with incident lymphoma.RMD open · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD5 is a critical regulator of the immune system and a transmembrane glycoprotein expressed on T cells and the surface of certain B cells. Over the years, numerous studies have demonstrated that CD5 is involved in the regulation of immune responses, maintenance of immune tolerance, and modulation of cell survival and apoptosis. Beyond these functions, CD5 also plays a role in immunotherapy, recognition of pathogen-associated molecular patterns, regulation of inflammatory processes, prediction of poor tumour prognosis, and clearance of macromolecules. Immune aberrant disorders-such as infections, chronic inflammation, malignancies, and autoimmune diseases-arise when the immune system becomes dysregulated. This study outlines the diverse and extensive biological functions of CD5 in relation to immunological abnormalities. A deeper understanding of CD5's specific roles in disease is expected to shed light on the complex pathophysiology of these conditions and may reveal novel therapeutic strategies and interventions for the management of immune-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.