ArticleMovement disorders clinical practice2025
Constipation in a Large Online Cohort of Persons with Parkinson's Disease.
Article in Movement disorders clinical practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Dysphagia Is Associated with Incident Non-Motor Symptoms in Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Development and emerging trends in gastrointestinal dysfunction of Parkinson's disease: a decade-long bibliometric analysis.Frontiers in aging neuroscience · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSmall studies suggest that constipation is a common symptom associated with a worse prognosis in patients with Parkinson's disease (PD).
objectivesThe aim was to compare the association between constipation, motor, and other non-motor symptoms (NMS) in PD patients at baseline and in future.
methodsUsing the Fox Insight database, we compared baseline characteristics, risk of progressive motor symptoms, and incidence of NMS between PD patients with versus without constipation.
resultsOf 20,352 participants, 16,611 (82%) reported infrequent bowel movements and/or excessive straining, 15,594 (77%) had incomplete evacuation, and 14,165 (70%) reported both symptoms. Patients with constipation were generally older, white, women, had PD >5 years, and had higher NMS and comorbidity scores (P < 0.001). Constipation was significantly associated with worse motor symptoms and most NMS, especially fecal incontinence (odds ratio [OR] = 1.65; 95% confidence interval [CI], 1.49-1.82), dysphagia (OR = 1.20; 95% CI = 1.12-1.29), talking/moving during sleep (OR = 1.39; 95% CI = 1.30-1.48), and urinary urgency (OR = 1.23; 95% CI = 1.16-1.32). Constipation was associated with a small, but statistically significant increased risk of some progressive motor symptoms. At a mean median follow-up of 2.8 years, constipation was associated with an increased risk of incident gastrointestinal, autonomic, neuropsychiatric, sleep-related, sensory NMS, such as dysphagia (hazard ratio [HR] = 1.43; 95% CI = 1.35-1.51), fecal incontinence (HR = 1.87; 95% CI = 1.74-2.01), falls (HR = 1.44; 95% CI = 1.35-1.52), hallucinations (HR = 1.65; 95% CI = 1.52-1.79), cognitive impairment (HR = 1.38; 95% CI = 1.30-1.47), and talking/moving during sleep (HR = 1.65; 95% CI = 1.55-1.75).
conclusionsConstipation is a common symptom associated with severity of motor and other NMS and portends a worse prognosis in persons with PD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.