Evidence map›Paper›PMID 40539450›Full record

ArticleMolecular medicine reports2025

Protective effects of lipid mediators, obtained from docosahexaenoic acid via soybean lipoxygenase, on lipopolysaccharide‑induced acute lung injury through the NF‑κB and Nrf2/HO‑1 signaling pathways.

Yan Su, Hack Sun Choi, Soon Kyu Kwon, Yunjon Han, Soon-Chang Cho, Jin Hyuk Shin, Yong-Suk Jang, Jong Hyun Choi, Jeong-Woo Seo

Abstract read
In one paragraph

Article in Molecular medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yan SuMicrobial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeonbuk 56212, Republic of Korea.
Hack Sun ChoiDepartment of Biochemistry and Molecular Biology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
Soon Kyu KwonMicrobial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeonbuk 56212, Republic of Korea.
Yunjon HanMicrobial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeonbuk 56212, Republic of Korea.
Soon-Chang ChoBiocorp Co., Ltd., Goheung‑gun, Jeollanam‑do 59551, Republic of Korea.
Jin Hyuk ShinBiocorp Co., Ltd., Goheung‑gun, Jeollanam‑do 59551, Republic of Korea.
Yong-Suk JangDepartment of Bioactive Material Sciences, Jeonbuk National University, Jeonju, Jeonbuk 54896, Republic of Korea.
Jong Hyun ChoiMicrobial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeonbuk 56212, Republic of Korea.
Jeong-Woo SeoMicrobial Biotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeonbuk 56212, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute lung injury (ALI), marked by acute and chronic inflammation, causes damage to alveolar epithelial and capillary endothelial cells. The present study investigated lipid mediators (LM) effects on lipopolysaccharide (LPS)‑induced RAW264.7 cells and ALI mice. LM, comprising 17S‑monohydroxy docosahexaenoic acid (DHA), resolvin D5 and protectin DX (in a 3:47:50 ratio), were derived from DHA via soybean lipoxygenase and demonstrated anti‑inflammatory properties.

Indexed as

Acute Lung InjuryDocosahexaenoic AcidsHeme Oxygenase-1LipoxygenaseNF-E2-Related Factor 2NF-kappa BSignal TransductionAnimalsGlycine maxLipopolysaccharidesMaleMiceNitric OxideOxidative StressRAW 264.7 CellsReactive Oxygen SpeciesDocosahexaenoic AcidsHeme Oxygenase-1LipopolysaccharidesLipoxygenaseNfe2l2 protein, mouseNF-E2-Related Factor 2NF-kappa BNitric OxideReactive Oxygen Speciesacute lung injuryinflammationNF‑κBnuclear factor erythroid 2‑related factor 2/heme oxygenase‑1oxidative stress

Identifiers

PMID40539450
PMCPMC12203040

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.