Evidence map›Paper›PMID 40539427›Full record

ArticleACS applied bio materials2025

A Peptide Hydrogel Responsive to Reactive Oxygen Species and pH for the Protection and Sustained Delivery of Insulin-like Growth Factor 1 in Osteoarthritis Treatment.

Dona Imanga Upamadi Edirisinghe, Ashmeet Singh, Michael Patrick Seitz, Alireza Jafar Esmaeili, Thalma Kabeyi Orado, Emma Herrero, Jennifer Jankowski, Precious Kemilembe Kairuki, Liam R Marshall, Era Jain and 1 more

Abstract read
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In one paragraph

Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dona Imanga Upamadi EdirisingheDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
Ashmeet SinghDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place, Waco, Texas 76798, United States.
Michael Patrick SeitzBiomedical and Chemical Engineering, Syracuse University, Bowne Hall, Syracuse, New York 13244, United States.
Alireza Jafar EsmaeiliDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
Thalma Kabeyi OradoBiomedical and Chemical Engineering, Syracuse University, Bowne Hall, Syracuse, New York 13244, United States.
Emma HerreroDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
Jennifer JankowskiDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
Precious Kemilembe KairukiDepartment of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.ORCID 0009-0009-7410-5298
Liam R MarshallDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place, Waco, Texas 76798, United States.
Era JainBiomedical and Chemical Engineering, Syracuse University, Bowne Hall, Syracuse, New York 13244, United States.ORCID 0000-0002-7172-401X
Olga V MakhlynetsDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place, Waco, Texas 76798, United States.ORCID 0000-0002-2763-7891

Funding

Metalloproteins: evolution, catalysis and material designR35GM155013 · NIGMS · BAYLOR UNIVERSITY · PI OLGA MAKHLYNETS · 2024 to 2026
$933k
NIGMS NIH HHS R35 GM155013
6 · The paper itself

Abstract

Osteoarthritis (OA) is the leading cause of disability in adults worldwide. This debilitating disease is associated with a relatively high concentration of reactive oxygen species (ROS) and reduced pH in the joints. In this regard, we devised a two-pronged approach to treating OA that combines ROS neutralization and stimuli-responsive drug delivery. Specifically, we developed a series of biocompatible, self-healing short peptide hydrogels that preserve their rheological properties in a wide range of biologically relevant salt concentrations. We evaluated the ROS-responsive release of a cartilage healing promoting growth factor (insulin-like growth factor 1, IGF-1) from these biomaterials. Furthermore, the ROS-responsive peptide hydrogel's ability to sequester ROS can potentially relieve disease-associated symptoms and minimize cell damage. The simplicity and effectiveness of this multistimuli-responsive smart biomaterial suggest promise in OA treatment.

Indexed as

Biocompatible MaterialsHydrogelsInsulin-Like Growth Factor IOsteoarthritisPeptidesReactive Oxygen SpeciesAnimalsDrug Delivery SystemsHumansHydrogen-Ion ConcentrationInsulin-Like PeptidesMaterials TestingParticle SizeBiocompatible MaterialsHydrogelsInsulin-Like Growth Factor IInsulin-Like PeptidesPeptidesReactive Oxygen Speciesdrug deliveryhydrogelIGF-1injectableosteoarthritispeptideROS

Identifiers

PMID40539427
PMCPMC13472177

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.