ArticleAlzheimer's & dementia (New York, N. Y.)
Alzheimer's disease genetic risk: Top African American risk allele frequencies and genetic architecture among Mexican-, African-, and non-Hispanic White Americans.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- RBFOX1 association with age at onset of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Alzheimer's disease genetic risk: Top African American risk allele frequencies and genetic architecture among Mexican-, African-, and non-Hispanic White Americans.Alzheimer's & dementia (New York, N. Y.)Article
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11 authors.
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Abstract
introductionAlzheimer's disease (AD) continues to be the sixth leading cause of death in the United States. Significant efforts are spent researching etiology and potential management strategies. Although minorities face a higher disease burden and are anticipated to make up 43% of the US population by 2060, most literature on inherited AD risk has been derived from studying European ancestry. Here we evaluate frequencies of top AD risk alleles for late-onset AD (LOAD) in African- (AA), Mexican- (MA) and non-Hispanic White (NHW)-American participants enrolled in the Health & Aging Brain Study-Health Disparities (HABS-HD) cohort to determine ethnicity-specific differential genetic architecture.
methodsUsing DNA extracted from this community-based diverse cohort (
resultsGenotype frequencies for 12 out of 15 SNPs (2 apolipoprotein E [ DISCUSSION: This analysis expands on our previous study supporting the notion that genetic risk for AD is heterogeneous across racial and ethnic populations. Our results continue to demonstrate the valuable nature of diversity in genetic risk investigations and suggest the importance of including diverse and underrepresented racial and ethnic populations in medical research. Perhaps the most interesting finding is observed in the SNPs not found to be significantly different between groups, indicating there may be shared pleiotropic gene architecture across ethnicities. Highlights: Alzheimer's disease (AD) burden is rapidly increasing in the United States; minorities are disproportionally affected.We investigate genetic health disparities in our community-based diverse cohort.Twelve of 15 evaluated single nucleotide polymorphisms significantly differ among ethnicities in the Health & Aging Brain Study-Health Disparities.
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