Evidence map›Paper›PMID 40539120›Full record

ArticleCytoJournal2025

Proposal for including risk of malignancy and clinical management in the Japanese system for reporting thyroid cytopathology - A multi-institutional study.

Mitsuyoshi Hirokawa, Ryohei Katoh, Takashi Amano, Tomohiro Chiba, Naoko Yamazaki, Shinya Satoh, Miyuki Towata, Yasuyo Ohi, Yukari Maeda, Mitsuhiro Fukushima and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CytoJournal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Recent topics on thyroid cytopathology: reporting systems and ancillary studies.Journal of pathology and translational medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Mitsuyoshi HirokawaDepartment of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan.
Ryohei KatohDepartment of Pathology, Ito Hospital, Shibuya, Japan.
Takashi AmanoDepartment of Clinical Pathology, Ito Hospital, Shibuya, Japan.
Tomohiro ChibaDepartment of Cytology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Koto, Japan.
Naoko YamazakiDepartment of Cytology, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Koto, Japan.
Shinya SatohDepartment of Endocrine Surgery, Yamashita Thyroid Hospital, Fukuoka, Japan.
Miyuki TowataDepartment of Clinical Laboratory, Yamashita Thyroid Hospital, Fukuoka, Japan.
Yasuyo OhiDepartment of Pathology, Sagara Hospital, Kagoshima, Japan.
Yukari MaedaDepartment of Pathology, Sagara Hospital, Kagoshima, Japan.
Mitsuhiro FukushimaThyroid Center, Showa Medical University Northern Yokohama Hospital, Yokohama, Japan.
Eiji SasakiThyroid Center, Showa Medical University Northern Yokohama Hospital, Yokohama, Japan.
Hironao YasuokaDepartment of Pathology, Osaka Rosai Hospital, Sakai, Japan.
Miyoko HiguchiDepartment of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan.
Ayana SuzukiDepartment of Diagnostic Pathology and Cytology, Kuma Hospital, Kobe, Japan.
Takashi AkamizuDepartment of Internal Medicine, Kuma Hospital, Kobe, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The Japanese System for Reporting Thyroid Cytopathology (JSRTC) does not include the risks of malignancies (ROMs) or recommended clinical management. This multi-institutional study aimed to determine the frequency, re-aspiration rate, resection rate, ROM, and clinical management options in seven different categories. Material and Methods: For 15,495 cases of thyroid fine-needle aspiration performed at seven Japanese institutions without molecular testing, the frequency, re-aspiration rate, resection rate, ROM, and clinical management options of each diagnostic category were examined. The categorization was based on JSRTC, and cases were subdivided into those with nuclear atypia and other subtypes for undetermined significance. Results: Re-aspiration of unsatisfactory and undermined significance diagnostic categories was mainly performed for cases of suspected malignancy on ultrasound. The median re-aspiration rate of cyst fluid nodules was 4.9%, which was significantly different from that (17.8%) of unsatisfactory cases ( Conclusion: Overall, this study determines the frequency, ROM, and recommended clinical management for thyroid cytopathology in Japan. These results were different from those proposed by the Bethesda System for Reporting Thyroid Cytopathology. In the future, our results will be helpful in the revision of JSRTC and will contribute to improving the outcomes among Japanese patients with thyroid nodules.

Indexed as

CytodiagnosisCytologyFine-needle aspirationRisk managementThyroid

Identifiers

PMID40539120
PMCPMC12178087

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.