Evidence map›Paper›PMID 40539069›Full record

ReviewFrontiers in immunology2025

Use of anakinra in cryopyrin-associated periodic syndromes: case report and review of literature.

Marta Salas Sánchez, Elena García-Martínez, Héctor Balastegui Martín, María Esther Durán-García, Cristina Lavilla Olleros

Abstract readCase ReportsReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. [Regulatory mechanisms of post-translational modifications in inflammasome signaling: a review].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marta Salas SánchezDepartment of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Elena García-MartínezImmunology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Héctor Balastegui MartínPrimary Immunodeficiencies Unit, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
María Esther Durán-GarcíaInstituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.
Cristina Lavilla OllerosDepartment of Internal Medicine, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cryopyrin-associated periodic syndrome is a rare autoinflammatory syndrome caused by a dysregulation of cytokine signaling pathways, particularly of the interleukin-1β production. Symptoms typical appear early in life and include recurrent fever, arthralgia, and cutaneous rash, often accompanied by systemic manifestations and progressive end-organ damage resulting from chronic inflammation. Interleukin- targeted therapy constitutes the basis for treatment, and can lead to complete resolution of symptoms. We report a case of a 66-year-old man with cryopyrin-associated periodic syndrome related to V198M mutation, successfully treated with anakinra, an interleukin- 1 inhibitor frequently used in rheumatoid arthritis.

Indexed as

Antirheumatic AgentsCryopyrin-Associated Periodic SyndromesInterleukin 1 Receptor Antagonist ProteinAgedHumansMaleMutationNLR Family, Pyrin Domain-Containing 3 ProteinTreatment OutcomeAntirheumatic AgentsInterleukin 1 Receptor Antagonist ProteinNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humananakinraautoinflammatory diseaseCAPScase reportcryopyrin-associated periodic syndrome

Identifiers

PMID40539069
PMCPMC12176851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.