ArticleFrontiers in immunology2025
Single-cell sequencing reveals dysregulated cell type perturbations and critical mediator communication remodelling in colorectal cancer.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Article
- Uncovering cellular perturbations and key mediator communications in liver cancer using single-cell RNA sequencing.Frontiers in immunology · 2026Article
- A novel prognostic model for ovarian cancer: construction, validation, and therapeutic insights.Frontiers in genetics · 2026Article
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Authors and funding
7 authors.
Funding
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Abstract
Background: The heterogeneity of colorectal cancer (CRC) and its complex immune microenvironment pose significant challenges for treatment. Understanding the cellular composition and dynamic changes is essential for uncovering mechanisms of tumour progression. Methods: To investigate the cellular heterogeneity and immune microenvironment of CRC, identifying critical subpopulations, functional pathways, and prognostic biomarkers, single-cell transcriptomic data from 41 CRC samples across four datasets were integrated. Bioinformatic analyses identified cellular subpopulations, cell communication networks, and prognostic biomarkers. The expression patterns, clinical significance and biological function of Results: A distinct epithelial subpopulation with proliferative and invasive features was identified, promoting tumour progression by resisting apoptosis and remodelling the extracellular matrix. ActMono, a terminal state of myeloid cells, was enriched in tumours and linked to disease progression. Cell communication analysis highlighted galectin signalling in immune regulation. A prognostic model (CRS) based on secretory immune cell-related genes identified Conclusion: This study reveals critical subpopulations, signalling pathways, and biomarkers in CRC, providing insights into tumour progression and potential therapeutic strategies.
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