Evidence map›Paper›PMID 40539061›Full record

ArticleFrontiers in immunology2025

Impaired SREBP1-mediated regulation of lipid metabolism promotes inflammation in chronic endometritis.

Shigeru Matsuda, Yoshimitsu Kuwabara, Yoshitaka Taketomi, Yuki Nagasaki, Yosuke Sugita, Shunji Suzuki, Ichiro Manabe, Makoto Murakami, Yumiko Oishi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shigeru MatsudaDepartment of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Yoshimitsu KuwabaraDepartment of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Yoshitaka TaketomiLaboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yuki NagasakiLaboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yosuke SugitaDepartment of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Shunji SuzukiDepartment of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Ichiro ManabeDepartment of Systems Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Makoto MurakamiLaboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yumiko OishiDepartment of Medical Biochemistry, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic endometritis (CE) is an inflammatory disease of the uterus that is associated with infertility and poor reproductive outcomes. Although most cases of CE are attributed to bacterial infections, antibiotic treatment is sometimes ineffective, and the mechanisms underlying the development and persistence of inflammation in CE are poorly understood. In the present study, we established a novel mouse model of CE that causes fetal death without affecting implantation and demonstrated that dysregulation of lipid metabolism contributes to its pathology. A deficiency in SREBP1, a key regulator of lipid metabolism, prolonged endometrial inflammation with CD138

Indexed as

EndometritisLipid MetabolismSterol Regulatory Element Binding Protein 1Abortion, SpontaneousAnimalsChronic DiseaseDisease Models, AnimalEicosapentaenoic AcidEndometriumFemaleHumansInflammationMiceMice, Inbred C57BLMice, KnockoutPhospholipidsEicosapentaenoic AcidPhospholipidsSrebf1 protein, mouseSterol Regulatory Element Binding Protein 1chronic endometritisEPAinfertility treatmentPUFAreccurrent pregnancy loss

Identifiers

PMID40539061
PMCPMC12176762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.