Evidence map›Paper›PMID 40538986›Full record

ArticleFrontiers in nuclear medicine2025

Evaluating image-derived input functions for cerebral [

Giordana Salvi de Souza, Pascalle Mossel, Joost F Somsen, Laura Providência, Anna L Bartels, Antoon T M Willemsen, Rudi A J O Dierckx, Cristiane R G Furini, Adriaan A Lammertsma, Charalampos Tsoumpas and 1 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05618119 (The Impact of Gender Differences in P-glycoprotein Function Measured With [18F]MC225 and PET), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05618119 naunknown statusnot on this map

The Impact of Gender Differences in P-glycoprotein Function Measured With [18F]MC225 and PET

TypeinterventionalSponsorUniversity Medical Center GroningenRan2023 to 2025Enrolled10ConditionsGenderArms[18F]MC225
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. FromACS omega · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giordana Salvi de SouzaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Pascalle MosselDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Joost F SomsenDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Laura ProvidênciaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Anna L BartelsDepartment of Neurology, Ommelander Ziekenhuis Groep, Scheemda, Netherlands.
Antoon T M WillemsenDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Rudi A J O DierckxDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Cristiane R G FuriniSchool of Medicine, PUCRS, Porto Alegre, Brazil.
Adriaan A LammertsmaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Charalampos TsoumpasDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Gert LuurtsemaDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Kinetic modelling of brain PET data is crucial for estimating quantitative biological parameters, traditionally requiring arterial sampling. This study evaluated whether arterial samples could be omitted to estimate the image-derived input function (IDIF) using a long axial field-of-view PET scanner. The use of internal carotid arteries (ICA) for IDIF estimation, along with venous samples for plasma-to-whole blood ratios and plasma parent fractions, was also assessed. Six healthy volunteers underwent [ Trial Registry: NCT05618119 (clinicaltrials.gov/study/NCT05618119).

Indexed as

IDIFkinetic analyseslong axial field of view PETpharmacokineticsquantitative analysisvenous sampling

Identifiers

PMID40538986
PMCPMC12176838

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.