Evidence map›Paper›PMID 40538931›Full record

ArticleFrontiers in pediatrics2025

Heart rate variability and amplitude-integrated electroencephalography measured shortly after birth and time to reach clinical milestones: a pilot study in late preterm infants.

Birju A Shah, Samantha Latremouille, Sanjay Chawla, Martin Keszler, Richard Tucker, Abbot Laptook, Guilherme M Sant'anna

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02156817 (Neurophysiologic Maturation Index), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02156817 completednot on this map

Neurophysiologic Maturation Index: NEMO Project for Late Preterm Infants

TypeobservationalSponsorBrown UniversityRan2014 to 2017Enrolled26ConditionsNeurophysiologic MaturationArmsAmplitude integrated electroencephalogram, Cardiorespiratory signal acquisition
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Birju A ShahDepartment of Pediatrics, University of Oklahoma Health College of Medicine, Oklahoma City, OK, United States.
Samantha LatremouilleDepartment of Pediatrics, McGill University Health Centre, Montreal, QC, Canada.
Sanjay ChawlaDepartment of Pediatrics, Wayne State University, Detroit, MI, United States.
Martin KeszlerWarren Alpert Medical School, Brown University, Providence, RI, United States.
Richard TuckerWarren Alpert Medical School, Brown University, Providence, RI, United States.
Abbot LaptookWarren Alpert Medical School, Brown University, Providence, RI, United States.
Guilherme M Sant'annaDepartment of Pediatrics, McGill University Health Centre, Montreal, QC, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Among late preterm (LPT) infants, there is significant variability in reaching milestones for safe discharge. We examined the associations of early measures of heart rate variability (HRV) and amplitude-integrated electroencephalogram (aEEG) with time to wean to an open-air cot and to achieve full oral feeds. Methods: This is a prospective, multicenter observational cohort study that enrolled infants between 34 Results: Of the 26 infants from three centers, 23 were included for analysis for time to an open-air cot. The analysis for time to full oral feeds was limited to 19 infants from two centers with similar feeding policies. Including HRV parameters ( Conclusions: Early measurements of HRV and aEEG parameters correlate with time to an open-air cot and to achieve full oral feeds in LPT infants born between 34

Indexed as

biomarkersclinical milestonesdevelopmental maturationlate preterm babieslength of hospital admissionneonatal morbiditiesneurophysiological assessment

Identifiers

PMID40538931
PMCPMC12176856

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.