A predictive model to identify optimal candidates for surgery among patients with metastatic colorectal cancer.

Purpose: To improve clinical decision-making, we developed a predictive model to identify metastatic colorectal cancer (mCRC) patients who might benefit from primary tumor resection (PTR). Patients and Methods: We extracted clinical data of stage IV CRC patients between 2010 and 2019 from the Surveillance, Epidemiology, and End Results database. Propensity score matching (PSM) was used to balance confounding factors by categorizing patients into surgery and non-surgery groups. To identify independent predictors of cancer-specific survival (CSS), we used multivariate Cox regression analysis. We further sorted patients who underwent surgery into benefit and non-benefit groups based on the median CSS of the non-surgery group; subsequently, we split the groups into training and test sets at a ratio of 6:4. To construct predictive models, we used the Boruta selection method to further filter variables, focusing on whether patients benefited from the surgery, based on key predictive factors. Results: We identified 23,649 mCRC patients, of whom 80.97% (19,148) underwent PTR. After PSM, compared to no surgical intervention, surgical intervention was independently associated with an extended median CSS [median: 22 Conclusion: We achieved a predictive model which could identify optimal candidates for PTR among mCRC patients with high accuracy.