Evidence map›Paper›PMID 40538763›Full record

ArticleBioactive materials2025

Near-field electrospun 3D anisotropic fiber-hydrogel scaffold integrated with photothermal effect for skin wound healing.

Ruinan Hao, Hongtao Hu, Xilin Ye, Xiaofeng Chen, Jinzhi Du, Shuolei Li, Chenglin Song, Feng Tian, Nana Zhao, Fujian Xu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Synergistic phototherapy and CaBioactive materials · 2026
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ruinan HaoTrauma Center, Peking University People's Hospital, Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, National Center for Trauma Medicine, Beijing, 100044, PR China.
Hongtao HuState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Xilin YeState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Xiaofeng ChenTrauma Center, Peking University People's Hospital, Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, National Center for Trauma Medicine, Beijing, 100044, PR China.
Jinzhi DuSchool of Medicine, South China University of Technology, Guangzhou, 510006, PR China.
Shuolei LiLaboratory Animal Unit, Peking University, People's Hospital, Beijing, 100044, PR China.
Chenglin SongTrauma Center, Peking University People's Hospital, Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, National Center for Trauma Medicine, Beijing, 100044, PR China.
Feng TianState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Nana ZhaoState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Fujian XuState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.
Tao ZhangDepartment of Vascular Surgery, Peking University People's Hospital, Beijing, 100044, PR China.
Feng RaoTrauma Center, Peking University People's Hospital, Key Laboratory of Trauma and Neural Regeneration, Ministry of Education, Peking University, National Center for Trauma Medicine, Beijing, 100044, PR China.
Jiajia XueState Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wound healing remains a critical clinical challenge due to inflammatory responses, oxidative stress in the wound microenvironment, and impaired tissue remodeling. In this study, an anisotropic scaffold was developed by integrating photothermal stimulation with topographical cues to modulate wound healing. The scaffold consisted of gelatin methacryloyl (GM) hydrogel and radially aligned poly (ε-caprolactone) (PCL) fibers integrated with polydopamine (PDA). The anisotropic scaffold not only exhibited anti-inflammatory effects but also enabled localized thermal stimulation under near-infrared (NIR) light to promote wound healing. It guided cell migration and proliferation from the wound edge toward the center, while the GM hydrogel maintained a moist environment and mitigated uncontrolled thermal damage. In a full-thickness skin wound model in rats, the anisotropic scaffold accelerated wound healing, epidermal regeneration, angiogenesis, and collagen deposition. This approach offers a safe, efficient, and bioactive-factor-free therapeutic strategy for wound repair, showing great potential for clinical translation.

Indexed as

Cell migrationMild heat stimulationNear-field electrospinningRadially aligned fibersWound healing

Identifiers

PMID40538763
PMCPMC12176689

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.