Evidence map›Paper›PMID 40538751›Full record

ArticleMaterials today. Bio2025

Extracellular matrix-degradable polymer nanostimulants elicit potent immune responses in orthotopic pancreatic cancer via sono-activatable dual-drug synergism.

Meng Li, Danling Cheng, Yue Wang, Chongwen Xuan, Viktar Abashkin, Jindong Xia, Ling Ding, Jingchao Li

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Organic Semiconducting Polymers for Cancer Sonodynamic Immunotherapy.Polymer science & technology (Washington, D.C.) · 2026
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Meng LiState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Danling ChengState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Yue WangDepartment of Radiology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Chongwen XuanState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Viktar AbashkinInstitute of Biophysics and Cell Engineering of NASB, 27 Akademicheskaya St., 220072, Minsk, Belarus.
Jindong XiaDepartment of Radiology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China.
Ling DingState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.
Jingchao LiState Key Laboratory of Advanced Fiber Materials, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer is a highly aggressive malignancy with a poor prognosis due to its complex tumor microenvironment (TME), which includes a dense extracellular matrix (ECM) and immunosuppressive pathways. Nanomedicine capable of achieving profound tumor penetration and modulating the tumor immune microenvironment is urgently needed to enhance the efficacy of cancer therapy. Herein, we introduce ECM-degradable semiconducting polymer nanostimulants (SPNs) as a novel nanostimulant for deep tumor penetration and multifaceted remodeling of the tumor microenvironment. The SPNs were constructed by loading two immune drugs: toll-like receptor 7/8 agonist (R848) and indoleamine 2,3-dioxygenase inhibitor (NLG919), onto singlet oxygen (

Indexed as

ImmunotherapyOrthotopic pancreatic cancerPolymer nanoparticlesSonodynamic therapyTumor microenvironment

Identifiers

PMID40538751
PMCPMC12178713

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.