ArticleFrontiers in veterinary science2025
Combined effects of quinic acid and isochlorogenic acid B on LPS-induced inflammation and pyroptosis in MAC-T cells and mouse mammary glands.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The NLRP3 Inflammasome as a Central Driver of Mastitis Pathogenesis: A Review.Veterinary sciences · 2026Review
- Selenium alleviates Staphylococcus aureus-induced mastitis by modulating mitochondrial dynamics and inhibiting the ROS/NLRP3/Pyroptosis pathway.Molecular biology reports · 2025Article
- Isolation, identification, and susceptibility testing ofFrontiers in veterinary science · 2025Article
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Authors and funding
5 authors.
Funding
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Abstract
Introduction: Quinic acid (QA) and isochlorogenic acid B (ICAB) have been demonstrated to possess antioxidant, anticancer, and anti-inflammatory properties. However, their combined efficacy in protection against mastitis requires further investigation. This study aims to examine the inhibitory effects and mechanisms of QA and ICAB combination on lipopolysaccharide (LPS)-induced inflammation and pyroptosis in bovine mammary epithelial cells (MAC-T) and mouse mammary tissue. Methods: The optimal concentrations of QA and ICAB for treating MAC-T cells were determined using Cell Counting Kit-8 (CCK-8). Expression levels of inflammatory factors, oxidative stress and pyroptosis indicators were assessed by ELISA. Immunohistochemistry was employed to detect CD3 levels in mouse mammary glands, while Western blot and immunofluorescence techniques were used to measure the expression levels of NOD-like receptor 3 (NLRP3) inflammasome, caspase-11, gasdermin D (GSDMD), and p65 of nuclear factor κB (NF-κB) in MAC-T cells. Results: QA (60 μg/mL) and ICAB (20 μg/mL) co-treatment significantly enhanced MAC-T cell activity ( Conclusion: QA and ICAB synergistically inhibits the inflammatory response and pyroptosis in MAC-T cells and mouse mammary glands through modulation of NF-κB pathway and NLRP3 inflammasome. This study contributes novel insights into combination of QA and ICAB in the prevention and treatment of mastitis.
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