ReviewWomen's health reports (New Rochelle, N.Y.)2025
Exploring Antibiotic-Mediated Disruption of Enterohepatic Circulation and Combined Oral Contraceptive Efficacy: A Systematic Review.
Review in Women's health reports (New Rochelle, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Combined oral contraceptives (COCs) are essential for the well-being and reproductive health of millions of women globally. Despite their widespread use, concerns among clinicians persist about potential drug-drug interactions between antibiotics and COCs. This systematic review evaluates existing literature on the interaction between antibiotics and COC efficacy, offering guidance for clinicians in managing the use of contraception alongside antibiotics. Materials and Methods: Utilizing Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines, a comprehensive literature search was conducted using PubMed, Clinical Trials.gov, Cochrane Library, and Google Scholar, focusing on studies published from 2000 to 2024. The search strategy was centered on peer-reviewed observational and experimental studies. Results: Initial analysis of the databases resulted in 712 potential articles. Nine articles were chosen relative to specific inclusion and exclusion criteria. While most antibiotics did not compromise COC effectiveness, enzyme-inducing antibiotics, particularly rifampicin, significantly reduced COC efficacy. Conclusion: Although common antibiotics pose minimal risk to COC effectiveness, clinicians should remain vigilant when prescribing enzyme-inducing antibiotics such as rifampicin. When these antibiotics are used, it is advisable to consider additional or alternative contraceptive methods to ensure continued pregnancy prevention.
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Registered trials
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