ArticleFrontiers in neurology2025
Cerebral hemodynamics and functional connectivity changes in stroke patients with dysphagia under acidic taste stimulation: a preliminary study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effect of Sour Taste on Swallowing Function of Patients With Dysphagia After Acute Ischemic Stroke: A Randomized Controlled Trial.Brain and behavior · 2026Trial
- Efficacy and Mechanisms of Combined Central-Peripheral Magnetic Stimulation on Prefrontal-Sensorimotor Cortex Connectivity in Post-Stroke Dysphagia after Supratentorial Stroke: A Randomized, Single-Blind, Parallel-Controlled Trial.Translational stroke research · 2026Trial
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10 authors.
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Abstract
Background: Swallowing difficulties after a stroke are a common complication that significantly impact the quality of life of patients. The cortical activation patterns in patients with dysphagia following a stroke may be influenced by different taste stimuli, but the underlying neural mechanisms remain unclear. Objectives: The aim of this study was to investigate the changes in brain cortical hemodynamic signals and functional connectivity in stroke patients with dysphagia during acidic taste stimulation. Methods: We recruited 15 patients with first-time swallowing difficulties due to stroke (53% male; mean age 69 ± 9.43 years; duration 2.47 ± 1.31 months post-stroke, onset between 2 weeks and 6 months). A 41-channel functional near-infrared spectroscopy (fNIRS) was used to measure changes in concentrations of oxygenated hemoglobin (HbO Results: During acidic taste stimulation, significant activation of multiple cortical regions, including Dorsolateral Prefrontal Cortex (DLPFC), Supplementary Motor Cortex (PSMC), and Primary Somatosensory Cortex (PSC) was observed compared to the neutral water condition ( Conclusion: This study demonstrates that acidic taste stimulation can significantly activate multiple cortical regions in stroke patients with dysphagia and enhance the connectivity strength of brain functional networks, which may have a positive effect on swallowing function regulation. These findings provide a theoretical basis for future taste-based neurorehabilitation interventions and offer new insights into the treatment strategies for dysphagia after stroke.
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