Evidence map›Paper›PMID 40538519›Full record

ArticleSAGE open medical case reports2025

Bolus doses of insulin versus a continuous insulin infusion for treating hyperkalaemia in adults: A case series.

Nicole King, Neil Martinson, Mmakwata Lesudi, Ebrahim Variava

Abstract readCase Reports
In one paragraph

Article in SAGE open medical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nicole KingDepartment of Internal Medicine, University of the Witwatersrand, Johannesburg, and Klerksdorp Tshepong Hospital Complex, North West Department of Health, South Africa.ORCID https://orcid.org/0009-0008-6378-0987
Neil MartinsonPerinatal HIV Research Unit (PHRU), Infectious Diseases and Oncology Research Institute, University of the Witwatersrand, Johannesburg, South Africa.ORCID https://orcid.org/0000-0002-0184-5705
Mmakwata LesudiDepartment of Internal Medicine, University of the Witwatersrand, Johannesburg, and Klerksdorp Tshepong Hospital Complex, North West Department of Health, South Africa.
Ebrahim VariavaDepartment of Internal Medicine, University of the Witwatersrand, Johannesburg, and Klerksdorp Tshepong Hospital Complex, North West Department of Health, South Africa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperkalaemia is a medical emergency that may manifest with a spectrum of cardiac conduction abnormalities and, if not promptly managed, can progress to cardiac arrest. While standard management typically involves stat doses of insulin to lower serum potassium, the optimal dosing regimen remains controversial. Patients whose serum potassium exceeds the upper normal limit by more than 1 mmol/L often require repeated conventional management to shift potassium intracellularly - usually every 2 to 4 h. Although dialysis is indicated in patients with concomitant renal dysfunction, its availability in resource-constrained settings is limited. We present three cases of symptomatic hyperkalaemia successfully managed with continuous insulin infusions, thereby obviating the need for dialysis. These cases underscore the potential role of continuous insulin infusions as an alternative strategy for correcting hyperkalaemia in settings where dialysis is not immediately available.

Indexed as

heart blockhyperkalaemiainsulin infusion

Identifiers

PMID40538519
PMCPMC12177256

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.