Evidence map›Paper›PMID 40538500›Full record

ArticleMediators of inflammation2025

S100A11 Promotes Acute Pancreatitis by Upregulating Acinar Cell Ferroptosis.

Huiyun Zhu, Hongxin Sun, Xianzhu Zhou, Ge Li, Yun Zhang, Youhan Zhang, Jia Gui, Siying Fei, Xiaoyang Dong, Xiaoju Su and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mediators of inflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Huiyun ZhuDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0003-4580-8700
Hongxin SunDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Xianzhu ZhouDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Ge LiClinical Research Center, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Yun ZhangClinical Research Center, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Youhan ZhangDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Jia GuiDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Siying FeiDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Xiaoyang DongDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Xiaoju SuDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.
Yan ChenDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0003-3788-9491
Cui ChenDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.ORCID https://orcid.org/0009-0009-6584-9455
Yiqi DuDepartment of Gastroenterology, The First Affiliated Hospital of Naval Medical University, 168 Changhai Road, Shanghai 200433, China.ORCID https://orcid.org/0000-0001-9330-0069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute pancreatitis (AP) is a common gastrointestinal disease that can cause systemic inflammation and lead to dysfunction of multiple organs. In pancreatitis, ferroptosis promotes disease progression and organ damage by regulating oxidative stress and inflammatory response. Here, ferroptosis was significantly elevated in the AP rat model and participated in regulating disease progression. Meanwhile, the expression of S100A11 was significantly upregulated in the pancreatic tissue of rats with AP, as determined by tandem mass spectrometry (TMT) proteomics. This phenomenon was also confirmed in pancreatic acinar cells. To reveal whether S100A11 participates in regulating ferroptosis, an S100A11 knockdown lentivirus was transfected into caerulein-treated pancreatic acinar cells AR42J. Functional results revealed that S100A11 knockdown significantly increased cell viability and GSH levels, while decreasing reactive oxygen species (ROS), lipid ROS, and Fe

Indexed as

Acinar CellsFerroptosisPancreatitisS100 ProteinsAnimalsCell LineCell SurvivalCeruletideMaleOxidative StressRatsRats, Sprague-DawleyReactive Oxygen SpeciesUp-RegulationCeruletideReactive Oxygen SpeciesS100 Proteinsacute pancreatitisferroptosispancreatic acinar cellsS100A11

Identifiers

PMID40538500
PMCPMC12178737

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.