Evidence map›Paper›PMID 40538466›Full record

ArticlePulmonary circulation2025

The Impact of Cardiac Output Methods on the Classification of Pulmonary Hypertension.

Léon Genecand, Gaëtan Simian, Mona Lichtblau, Jean-Marc Fellrath, Julian Klug, Hugues Turbé, Christian Lovis, Stéphane Noble, Julie Wacker, Julian Müller and 7 more

Abstract read
In one paragraph

Article in Pulmonary circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Léon GenecandDivision of Pulmonary Medicine, Department of Medicine Geneva University Hospitals Geneva Switzerland.ORCID https://orcid.org/0000-0001-6965-0480
Gaëtan SimianSection de mathématiques university of Geneva Geneva Switzerland.
Mona LichtblauDepartment of Pulmonology University of Zurich, University Hospital of Zurich Zurich Switzerland.
Jean-Marc FellrathService of Pulmonary Medicine Hopital Pourtales, Reseau Hospitalier Neuchâtelois Neuchâtel Switzerland.
Julian KlugFaculty of Medicine University of Geneva Geneva Switzerland.ORCID https://orcid.org/0000-0002-4849-9811
Hugues TurbéDivision of Medical Information Sciences University Hospitals of Geneva and University of Geneva Geneva Switzerland.
Christian LovisDivision of Medical Information Sciences University Hospitals of Geneva and University of Geneva Geneva Switzerland.
Stéphane NobleFaculty of Medicine University of Geneva Geneva Switzerland.
Julie WackerFaculty of Medicine University of Geneva Geneva Switzerland.
Julian MüllerDepartment of Pulmonology University of Zurich, University Hospital of Zurich Zurich Switzerland.
Roberto DespondsSection de mathématiques university of Geneva Geneva Switzerland.
Maurice BeghettiFaculty of Medicine University of Geneva Geneva Switzerland.
Benoit LechartierDivision of Respiratory Medicine Lausanne University Hospital Lausanne Switzerland.
David MontaniUniversité Paris-Saclay, School of Medicine Le Kremlin-Bicêtre France.
Olivier SitbonUniversité Paris-Saclay, School of Medicine Le Kremlin-Bicêtre France.
Silvia UlrichDepartment of Pulmonology University of Zurich, University Hospital of Zurich Zurich Switzerland.
Frédéric LadorFaculty of Medicine University of Geneva Geneva Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac output is essential to calculate pulmonary vascular resistance (PVR) and classify pulmonary hypertension (PH). Recent evidence has shown a lower agreement between thermodilution (COTD) and direct Fick (CODF) methods than historically estimated. The influence of the cardiac output measurement method on the classification of PH is poorly explored. We aimed to estimate the risk of diagnostic error when using COTD instead of CODF. We used a previously published mathematical model to consecutive patients diagnosed with PH at three centers in Switzerland. This model allows an individual estimation of the risk of diagnostic error when using COTD instead of CODF and is based on limits of agreement (LoA) between COTD and CODF of 2 L/min (average estimation) and 2.7 L/min (worst case scenario estimation). One thousand one hundred and forty-two patients with PH were evaluated. The mean risk of diagnostic error using the model with LoA of 2 L/min was 6.0% in the overall population (

Indexed as

cardiac outputdirect fickpulmonary hypertensionthermodilution

Identifiers

PMID40538466
PMCPMC12177550

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.