ArticleFrontiers in medicine2025
Predictive value of preoperative inflammatory response markers on short-term postoperative complications following colorectal surgery: a secondary analysis of a randomized clinical trial.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- An inflammation-nutrition composite index and its dynamic change for predicting postoperative wound complications.Langenbeck's archives of surgery · 2026Observational
- Article
- Postoperative dynamics of inflammatory markers in patients with uncomplicated recovery after colorectal cancer surgery: a preliminary inflammatory benchmarks study.Scientific reports · 2026Article
- Perioperative biomarkers and graft function in living donor kidney transplantation: focus on postoperative prognostic nutritional index.BMC nephrology · 2026Article
- Longitudinal Assessment of Hematologic and Immunonutritional Biomarkers from Treatment Initiation to Progression in Metastatic Colorectal Cancer.Biomedicines · 2026Article
- The Predictive Value of Clinical and Systemic Inflammatory Biomarkers in Emergency Colic Cancer Surgery: A Retrospective Study.Journal of clinical medicine · 2026Article
- Preoperative social frailty and short-term postoperative outcomes in gastrointestinal cancer surgery: a multicentre prospective cohort study in China.World journal of surgical oncology · 2026Observational
- Immunologically-based nutritional status assessment amongst preoperative colorectal cancer patients - does it link to TNM stage.Frontiers in immunology · 2026Article
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5 authors.
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Abstract
Background: Numerous inflammatory biomarkers have been identified to possess a positive prognostic value in relation to the clinical outcomes of patients with various cancers. Despite this, there is a paucity of comprehensive studies that compare the prognostic value of commonly used inflammatory parameters specifically within colorectal cancer (CRC) populations. These parameters include the peripheral blood neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), albumin-to-globulin ratio (AGR), and prognostic nutritional index (PNI). Thus, the objective of this research was to conduct a thorough comparison of the predictive potential value of preoperative commonly used inflammatory response markers in CRC patients. Methods: This is a retrospective, single-center cohort analysis. We performed a secondary analysis of 392 individuals with CRC who fulfilled our inclusion criteria and were admitted to the First Affiliated Hospital of Xi'an Jiaotong University between June 2018 and August 2019. Initially, the clinical data including baseline demographics, laboratory indices, type of surgery, type of anesthesia, and postoperative complications were collected. Then, the prognostic efficacy and threshold values of preoperative inflammatory biomarkers were ascertained through the employment of receiver operating characteristic (ROC) curves. Finally, both univariate and multivariate analyses were conducted to discern the risk factors contributing to postoperative complications with CRC patients. Results: In the present study, 54 (13.78%) patients experienced surgical complications. According to ROC curve analysis, PNI possessed the strongest predictive ability for surgical complications (AUC = 0.706, 95% CI = 0.642-0.770; Conclusion: Preoperative PNI possesses superior ability and serves as an independent predictor of clinical complications following colorectal resection surgery. Multidisciplinary teams should focus on addressing patients' immunonutrition status before surgery.
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