Evidence map›Paper›PMID 40538305›Full record

ArticleJournal of psychopharmacology (Oxford, England)2025

Adolescent substance use trajectories are associated with nucleus accumbens functional connectivity.

Juliann B Purcell, Heather E Dark, Sylvie Mrug, Marc N Elliott, Susan Tortolero Emery, Mark A Schuster, David C Knight

Abstract read
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In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juliann B PurcellDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Heather E DarkDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Sylvie MrugDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.
Marc N ElliottRAND, Santa Monica, CA, USA.
Susan Tortolero EmerySchool of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Mark A SchusterKaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA.
David C KnightDepartment of Psychology, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-1094-801X

Funding

Neurobiological Mechanisms of Lower Internalizing Disorders in Black AmericansR01MH098348 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KNIGHT, DAVID C, MRUG, SYLVIE · 2012 to 2016
$2.9M
Investigating the Effects of Alcohol and Substance Use During Adolescence Using Multimodal NeuroimagingF31AA027137 · NIAAA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PURCELL, JULIANN B · 2018 to 2020
$110k
NCCDPHP CDC HHS U19 DP002663NCCDPHP CDC HHS U19 DP002664NCCDPHP CDC HHS U19 DP002665NCCDPHP CDC HHS U48 DP000046NCCDPHP CDC HHS U48 DP000056NCCDPHP CDC HHS U48 DP000057NIAAA NIH HHS F31 AA027137NIMH NIH HHS R01 MH098348
6 · The paper itself

Abstract

backgroundAdolescent substance use is associated with disrupted communication among brain regions underlying reward-driven behaviors (e.g., nucleus accumbens (NAcc)) and cognitive/emotional control (e.g., prefrontal cortex (PFC); medial temporal lobe), which may be linked to poor future outcomes (e.g., substance use disorder). However, the relationship functional brain connectivity has with trajectories of adolescent alcohol, tobacco, and cannabis use has received limited attention.

aimsInvestigate relationships between adolescent substance use trajectories and young adult whole-brain NAcc resting-state functional connectivity (rsFC).

methodsSubstance use was assessed at ages 11, 13, 16, and 19. Subsequently (age 20), a subset of participants ( HYPOTHESES: Substance use trajectories representing greater age 14 usage, faster progression of use, and acceleration of use across adolescence would show stronger NAcc rsFC with regions implicated in cognitive/emotional control.

resultsAge 14 use (alcohol, tobacco, and cannabis) was associated with NAcc rsFC with dorsolateral PFC, dorsomedial PFC, parahippocampal gyrus (PHG), hippocampus, and amygdala. Progression of use was associated with NAcc rsFC with dorsolateral PFC, dorsomedial PFC, ventrolateral PFC, PHG, and amygdala. Finally, acceleration of use was linked with NAcc rsFC with dorsolateral PFC, ventromedial PFC, PHG, and hippocampus.

conclusionsNAcc rsFC with several brain regions (e.g., PFC subregions) varied with adolescent substance use, which may represent common neural mechanisms linking adolescent substance use with common psychological outcomes.

Indexed as

Nucleus AccumbensSubstance-Related DisordersAdolescentAdolescent BehaviorChildFemaleHumansMagnetic Resonance ImagingMalePrefrontal CortexRewardUnderage DrinkingYoung AdultadolescentfMRIlatent growth curve modelResting state functional connectivitysubstance use

Identifiers

PMID40538305
PMCPMC13616490

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.