ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Microsphere Strategy to Generate Conformal Bone Organoid Units with Osteoimmunomodulation and Sustainable Oxygen Supply for Bone Regeneration.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Mapping biomedical hydrogel microspheres through scientometric and topic modeling analysis of emerging nano-enabled design strategies.Discover nano · 2026Article
- Artificial intelligence virtual bone organoids (AIVBOs).Journal of orthopaedic translation · 2026Review
- Vascularized bone organoids: current advances and a biomimetic platform for osteonecrosis of the femoral head.Bone research · 2026Review
- Hydrogel Implementing Drug Delivery in Cranial Bone Tissue Engineering.Journal of functional biomaterials · 2026Review
- A Dual-Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation.Cell proliferation · 2026Article
- 3D bioprinted composite scaffold incorporating microfluidics-derived chondrocyte microspheroids promotes auricular cartilage regeneration.Materials today. Bio · 2026Article
- Bone Organoids as Advanced Models for Osteoporosis: Development, Application, and Future Prospects.International journal of molecular sciences · 2026Review
- Injectable Chondroitin Sulfate Methacrylate Hydrogel Microspheres Co-Loaded with GLPM Nanozyme, Dexamethasone, and Stem Cells for Synergistic Osteoarthritis Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- 3D printed HAMA/GelMA/lignosulfonate hydrogel integrating oxygen-releasing and antioxidative modules for liver regeneration.Journal of nanobiotechnology · 2026Article
- Hydroxyapatite-based bone repair biomaterials based on clinical heterogeneity: modification strategies, performance regulation, and personalized repair pathways.Frontiers in bioengineering and biotechnology · 2026Review
- Metabolism-Regulating Microspheres: Design Principles, Therapeutic Applications Across Multisystem Diseases, and Future Perspectives.Research (Washington, D.C.) · 2026Review
- Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects.MedComm · 2026Review
- A pH-Responsive Polysaccharide Hydrogel Modulates Oxygen Delivery and Immunometabolic Remodeling for Diabetic Bone Regeneration.Research (Washington, D.C.) · 2026Article
- Biodegradable piezoelectric PHB-BT nanofiber scaffolds combined with ultrasound stimulation to accelerate bone regeneration by regulating CaTheranostics · 2026Article
- Reactive Oxygen Species-Regulating Nanoengineered Hydrogels for Bone Regeneration: A Mechanism-Based Framework of Responsive Delivery, Intrinsic Scavenging, Nanozyme Catalysis, and Osteoimmunomodulation.International journal of nanomedicine · 2026Review
- Oxygen-releasing scaffolds in tissue engineering: design strategies, fabrication and regenerative applications.Regenerative biomaterials · 2026Review
- Hydrogel Microspheres for Biomedical Applications.Small science · 2026Review
- Microsphere Strategy to Generate Conformal Bone Organoid Units with Osteoimmunomodulation and Sustainable Oxygen Supply for Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
Repairing large bone defects remains a major challenge, as current strategies-including autografts, allografts, and tissue-engineered scaffolds-are limited by donor shortage, suboptimal biocompatibility, and insufficient control of the regenerative microenvironment. Bone organoids offer a promising strategy by simulating bone tissue functions and microenvironments in vitro, showing great potential for bone repair. However, current bone organoids still face issues such as insufficient oxygen supply, and limited immune modulation, reducing their effectiveness for complex bone defect repair, especially when precise shape conformity is required. To address these challenges, bone organoid unit based on silk hydrogel microspheres is developed, introducing oxygen-releasing components and immune cells to better mimic the bone repair environment and enable conformal filling of irregular defects. In vitro, the system formed bone organoid units through 28 days culture that sustained cell viability, promoted M2 macrophage polarization, and enhanced osteogenesis and angiogenesis. In a critical-sized mouse cranial defect model, this strategy outperformed traditional approaches, showing superior bone regeneration and tissue integration. These findings indicate that the strategy effectively addresses key obstacles in bone repair, such as oxygen supply, immune modulation, and shape conformity, providing a promising solution for personalized bone regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.