ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Nanoplastics Enhance Transmembrane Transport and Uptake of Carcinogens: Transcriptional Changes and the Effects of Weathering.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Nanoplastics and Neurodegeneration: A Roadmap From Mechanism to Causation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Rainbow Photonic Crystals: Self-Assembly of Carbohydrate Bottlebrushes Block Copolymers.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Article
- Nanoplastics Enhance Transmembrane Transport and Uptake of Carcinogens: Transcriptional Changes and the Effects of Weathering.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Nanoplastics are generated from common consumer plastics (polyethylene terephthalate, high-density polyethylene, polystyrene, polyvinyl chloride) and exposed to simulated marine weathering for up to 10 weeks. Fourier-transform infrared spectroscopy and ζ-potential measurements reveal continuous changes in the composition of the nanoplastics, consistent with oxidation. Although the chemical composition and oxidation of the nanoplastics influence their ability to sorb polycyclic aromatic hydrocarbons (PAHs), for all investigated conditions, sorption of PAHs to nanoplastics achieves effective PAH concentrations that are orders of magnitude higher than the solubility limit in water. In an intestinal co-culture model membrane consisting of M cells and enterocytes, PAH-loaded nanoplastics enhance the overall PAH transport into and across the membrane, with HDPE achieving the highest intracellular PAH concentration. RNA sequencing of cell membranes exposed to nanoplastics reveals significant transcriptional changes, including upregulation of oxidative stress and detoxification pathways (NQO1, CYP1A1, CYP1B1), especially in response to PAH-loaded nanoplastics, while genes associated with basic cell functions, such as DNA repair (MACROD2) and division (KIF20A), are downregulated. These findings confirm the feasibility of nanoplastics to increase bioaccessibility and bioavailability of hydrophobic carcinogens and enhance cellular stress, which underscores the potential environmental and health impacts associated with nanoplastics as carriers of hydrophobic environmental toxins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.