Evidence map›Paper›PMID 40538220›Full record

ArticleEuropean journal of immunology2025

The Frequency but not the Phenotype of Circulating Peripheral T Helper Cells is Increased at Later Stages of Progression to Type 1 Diabetes.

Anna-Mari Schroderus, Andrea Hanel, Céline Vandamme, Viola Pitkänen, Marja Rytkönen-Nissinen, Merja Heinäniemi, Mikael Knip, Riitta Veijola, Jorma Toppari, Jorma Ilonen and 2 more

Abstract read
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In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Anna-Mari SchroderusDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-8517-0943
Andrea HanelFaculty of Health Sciences, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Céline VandammeDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Viola PitkänenDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Marja Rytkönen-NissinenDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Merja HeinäniemiFaculty of Health Sciences, Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland.
Mikael KnipTampere Center for Child Health Research, Tampere University Hospital, Tampere, Finland.
Riitta VeijolaResearch Unit of Clinical Medicine, Department of Pediatrics, Medical Research Center, Oulu University Hospital and University of Oulu, Oulu, Finland.
Jorma ToppariDepartment of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
Jorma IlonenImmunogenetics Laboratory, Institute of Biomedicine, University of Turku, Turku, Finland.
Johanna LempainenDepartment of Pediatrics, University of Turku and Turku University Hospital, Turku, Finland.
Tuure KinnunenDepartment of Clinical Microbiology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-1595-5371

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating follicular (cTfh) and peripheral (cTph) T helper cells have been demonstrated to be expanded in several autoimmune diseases, including type 1 diabetes (T1D). Here, we examined the frequencies and phenotypes of these cells at different stages of T1D development and addressed their phenotypic and clonal relationships by analyzing samples from 27 children with newly diagnosed T1D, 29 autoantibody-positive (AAb

Indexed as

Diabetes Mellitus, Type 1T-Lymphocytes, Helper-InducerAdolescentAutoantibodiesAutoimmunityChildChild, PreschoolDisease ProgressionFemaleHumansImmunophenotypingMalePhenotypeReceptors, CXCR5AutoantibodiesReceptors, CXCR5autoimmunityB cell‐helper T cellsT cellsT follicular helperT peripheral helperType 1 diabetes

Identifiers

PMID40538220
PMCPMC12179578

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.