ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
DNA Sequential Logic Circuits for Reversible Counters and Dynamic Biomolecular Sensing.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- DNA-Based Boolean Logic Gates for Molecular Computation and Biosensing: A Critical Review.Molecular biotechnology · 2026Review
- Dephosphorylation-regulated MNAzyme-PER cascade as a programmable converter for multi-task molecular actuation.Journal of nanobiotechnology · 2026Article
- Reset-free DNA logic circuits for real-time input processing and memory.Science advances · 2026Article
- Intelligent molecular logic computing toolkits: nucleic acid-based construction, functionality, and enhanced biosensing applications.Chemical science · 2025Review
- DNA Sequential Logic Circuits for Reversible Counters and Dynamic Biomolecular Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The capacity to retain and precisely release historical data at the right moments is typically managed by sequential logic circuits within computer systems. However, the reusability and autonomy of DNA sequential logic circuits still need to be developed. To bridge this gap, a series of sequential logic circuits are implemented by constructing a DNA strand replacement system regulated by a nicking enzyme (nickase). This nickase-integrated system dynamically resolves the thermodynamic-kinetic conflict, offering spatiotemporal control over strand displacement. These circuits include Set-Reset latches (SR-latches) constructed with NOR and NAND gates, along with Data latches (D-latches), are designed with simplicity, autonomy, and reusability. Furthermore, addition, subtraction, and reversible counters leveraging these foundational circuits are successfully constructed. These latches are further applied to transient miRNA recording, environmental toxin detection, and real-time ATP imaging in living cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.