Evidence map›Paper›PMID 40538137›Full record

ArticleExperimental physiology2026

Effects of soluble guanylyl cyclase stimulation on muscle oxygenation and exercise capacity in heart failure with mildly reduced ejection fraction.

Ramona E Weber, Kiana M Schulze, Andrew G Horn, Tyler E McCoach, Zachary J White, K Sue Hageman, Stephanie E Hall, Peter Sandner, Brad J Behnke, Timothy I Musch and 1 more

Abstract read
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ramona E WeberDepartment of Kinesiology, Kansas State University, Manhattan, Kansas, USA.ORCID 0000-0001-5110-270X
Kiana M SchulzeDepartment of Kinesiology, Kansas State University, Manhattan, Kansas, USA.ORCID 0000-0001-6467-5179
Andrew G HornDepartment of Kinesiology, Kansas State University, Manhattan, Kansas, USA.
Tyler E McCoachDepartment of Kinesiology, Kansas State University, Manhattan, Kansas, USA.
Zachary J WhiteDepartment of Anatomy & Physiology, Kansas State University, Manhattan, Kansas, USA.ORCID 0000-0002-2591-6002
K Sue HagemanDepartment of Anatomy & Physiology, Kansas State University, Manhattan, Kansas, USA.
Stephanie E HallDepartment of Anatomy & Physiology, Kansas State University, Manhattan, Kansas, USA.ORCID 0000-0001-8962-8475
Peter SandnerBayer HealthCare AG, Drug Discovery, Wuppertal, Germany.
Brad J BehnkeDepartment of Kinesiology, Kansas State University, Manhattan, Kansas, USA.
Timothy I MuschDepartment of Kinesiology, Kansas State University, Manhattan, Kansas, USA.
David C PooleDepartment of Kinesiology, Kansas State University, Manhattan, Kansas, USA.ORCID 0000-0003-2441-3793

Funding

DO HEART FAILURE AND AGING POTENTIATE DIAPHRAGM VASCULAR DYSFUNCTION?R15AG078060 · NIA · KANSAS STATE UNIVERSITY · PI BEHNKE, BRAD J, POOLE, DAVID C · 2021 to 2021
$456k
Role for Nrf2 and exercise in mitigating pulmonary hypertension-induced vascular dysfunctionF31HL170643 · NHLBI · KANSAS STATE UNIVERSITY · PI SCHULZE, KIANA MARIE · 2023 to 2024
$73k
ROLE OF ANGIOTENSIN-(1-7) AND DIAPHRAGM VASCULAR FUNCTION IN HEART FAILURE AND PROLONGED MECHANICAL VENTILATIONF31HL167618 · NHLBI · KANSAS STATE UNIVERSITY · PI HORN, ANDREW · 2023 to 2024
$72k
Bayer AG | Pharmaceuticals Bayer BG6342HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1F31HL167618-02HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1F31HL170643-02HHS | NIH | National Institute on Aging (NIA) 1R15AG078060KSU | College of Veterinary Medicine, Kansas State University (Kansas State University College of Veterinary Medicine) SMILE GrantKSU | Johnson Cancer Research Center, Kansas State University (JCRC)NHLBI NIH HHS F31 HL167618NHLBI NIH HHS F31 HL170643NIA NIH HHS R15 AG078060
6 · The paper itself

Abstract

Heart failure (HF) with a mildly reduced ejection fraction (HFmrEF; 40%-49%) is present in ≤25% of HF patients. Therapeutic treatment options for HFmrEF-associated exercise intolerance are limited. Nitric oxide (NO)-independent stimulation of soluble guanylyl cyclase to improve peripheral vasodilatation offers a novel approach to enhance skeletal muscle oxygenation (interstitial pressure of O

Indexed as

Exercise ToleranceHeart FailureMuscle, SkeletalOxygenSoluble Guanylyl CyclaseStroke VolumeAnimalsMaleMuscle ContractionNitric OxideOxygen ConsumptionPhysical Conditioning, AnimalPyrazolesPyridinesRatsRats, Sprague-Dawley3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridineNitric OxideOxygenPyrazolesPyridinesSoluble Guanylyl Cyclasecardiovascular diseasecyclic guanosine monophosphateexercise intolerancemoderate heart failurenitric oxideoxygen uptake kinetics

Identifiers

PMID40538137
PMCPMC12857507

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.