ArticleThe Journal of physiology2025
Input-specific bidirectional regulation of hippocampal CA3 pyramidal cell excitability.
Article in The Journal of physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- The hippocampal CA3 area implements sequence learning of discontinuous episodes.Communications biology · 2026Article
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Authors and funding
3 authors.
Funding
Abstract
High-frequency mossy fibre (MF) inputs trigger a sustained increase in excitability to perforant pathway (PP) inputs in CA3 pyramidal cells (CA3-PC) by reducing Kv1.2 levels at distal apical dendrites, known as long-term potentiation of intrinsic excitability (LTP-IE). LTP-IE enhances excitatory postsynaptic potential (EPSP)-to-spike coupling at PP synapses, facilitating Hebbian LTP of synaptic weights. Prolonged hyperexcitability is detrimental, yet it is little understood how LTP-IE is restored in CA3-PCs. Here we show that MF-induced LTP-IE can be reversed through the burst firing of a CA3-PC elicited by PP or recurrent synaptic inputs. This reversal was impeded by the oxidative bias of cellular redox state or intracellular Zn
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Registered trials
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