Evidence map›Paper›PMID 40538044›Full record

ArticleMicrobial biotechnology2025

Elucidating the Mechanism of Temporal Adaptation to Hydrogen Peroxide-Induced Oxidative Stress in Corynebacterium glutamicum.

Chang Yu, Wenjing Hu, Xiaoyu Li, Yu Lei, Dandan Gao, Meng Wang, Ping Zheng, Yan Zhu, Jibin Sun

Abstract read
In one paragraph

Article in Microbial biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. CRISPR-Cas9-driven genome editing inFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chang YuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Wenjing HuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Xiaoyu LiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Yu LeiTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Dandan GaoTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Meng WangTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.
Ping ZhengTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID https://orcid.org/0000-0001-9434-9892
Yan ZhuTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.ORCID https://orcid.org/0000-0001-7342-3782
Jibin SunTianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China.

Funding

National Key Research and Development Program of China 2020YFA0908300Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project TSBICIP-CXRC-073Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project TSBICIP-PTJJ-012
6 · The paper itself

Abstract

Corynebacterium glutamicum serves as a pivotal industrial chassis for biomanufacturing and an ideal model for studying the phylogenetically related pathogen Mycobacterium tuberculosis. Oxidative stress poses a critical challenge to microorganisms during aerobic industrial processes and immune cell-mediated antibacterial killing by perturbing cellular redox homeostasis, affecting central metabolism, and damaging the integrity of biomacromolecules. However, the intricate mechanisms underlying the dynamic defence of C. glutamicum, despite previous transcriptomic studies on acute and adaptive responses to oxidative stresses, remain largely unclear, hindering strain engineering for industrial applications and the development of effective antimicrobial treatments. In this study, the susceptibility of C. glutamicum to hydrogen peroxide (H

Indexed as

Adaptation, PhysiologicalCorynebacterium glutamicumHydrogen PeroxideOxidative StressGene Expression ProfilingGene Expression Regulation, BacterialHydrogen PeroxideCorynebacterium glutamicumhydrogen peroxideindustrial stressredox homeostasistranscriptomic analysis

Identifiers

PMID40538044
PMCPMC12179340

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.