Evidence map›Paper›PMID 40538025›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

The dynamics of cognitive decline toward Alzheimer's disease progression: Results from ADSP-PHC's harmonized cognitive composites.

Kaidi Kang, Panpan Zhang, Logan Dumitrescu, Shubhabrata Mukherjee, Michael L Lee, Seo-Eun Choi, Emily H Trittschuh, Jesse Mez, Andrew J Saykin, Katherine A Gifford and 6 more

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Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Kaidi KangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0922-5727
Panpan ZhangDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Logan DumitrescuVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Michael L LeeDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Seo-Eun ChoiDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Emily H TrittschuhDepartment of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA.
Jesse MezDepartment of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA.
Andrew J SaykinDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Katherine A GiffordDepartment of Anatomy & Neurobiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Rachel F BuckleyDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Xiaoting GaoJohnson & Johnson Innovative Medicine R&D, Shanghai, China.
Jianing DiJohnson & Johnson Innovative Medicine R&D, Shanghai, China.
Paul K CraneDepartment of Medicine, University of Washington, Seattle, Washington, USA.
Timothy J HohmanVanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Dandan LiuDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0002-7176-8346

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Leslie Michael Shaw · 2016 to 2026
$226.7M
The Health & Aging Brain Study - Health Disparities (HABS-HD)U19AG078109 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI Sid E O'Bryant · 2022 to 2026
$181.1M
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI CHENGJIE XIONG · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI LEURGANS, SUE E. · 1991 to 2020
$49.1M
National Alzheimer's Coordinating CenterU24AG072122 · NIA · UNIVERSITY OF WASHINGTON · PI STEPHENS, KARI A · 2021 to 2025
$45.8M
Health and Aging Brain among Latino Elders (HABLE-AT(N)) StudyR01AG058533 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI JOHNSON, LEIGH A, O'BRYANT, SID E · 2020 to 2025
$45.4M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
THE NIA GENETICS OF ALZHEIMER'S DISEASE DATA STORAGE SITEU24AG041689 · NIA · UNIVERSITY OF PENNSYLVANIA · PI LI-SAN WANG · 2012 to 2026
$42.3M
Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI Mariet Allen · 2023 to 2026
$42.0M
ADSP Phenotype Harmonization ConsortiumAlzheimer's Association Research FellowshipNIA NIH HHS DP2 AG082342NIA NIH HHS K99 AG061238NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P20 AG068024NIA NIH HHS P20 AG068053NIA NIH HHS P20 AG068077NIA NIH HHS P20 AG068082NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG062421NIA NIH HHS P30 AG062422NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG062715NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066462NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066506NIA NIH HHS P30 AG066507NIA NIH HHS P30 AG066508NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG066511NIA NIH HHS P30 AG066512NIA NIH HHS P30 AG066514NIA NIH HHS P30 AG066515NIA NIH HHS P30 AG066518NIA NIH HHS P30 AG066519NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072931NIA NIH HHS P30 AG072946NIA NIH HHS P30 AG072947NIA NIH HHS P30 AG072958NIA NIH HHS P30 AG072959NIA NIH HHS P30 AG072972NIA NIH HHS P30 AG072973NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS P30 AG072977NIA NIH HHS P30 AG072978NIA NIH HHS P30 AG072979NIA NIH HHS R00 AG061238NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG022018NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG029672NIA NIH HHS R01 AG042210NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG054047NIA NIH HHS R01 AG054073NIA NIH HHS R01 AG057739NIA NIH HHS R01 AG058533NIA NIH HHS R01 AG059716NIA NIH HHS R01 AG061028NIA NIH HHS R01 AG062826NIA NIH HHS R01 AG064614NIA NIH HHS R01 AG064877NIA NIH HHS R01 AG068193NIA NIH HHS R01 AG070862NIA NIH HHS R01 AG073439NIA NIH HHS R01 AG079142NIA NIH HHS R01 AG079280NIA NIH HHS R01 AG082730NIA NIH HHS R37 AG015473NIA NIH HHS R37 AG057739NIA NIH HHS R56 AG051876NIA NIH HHS RF1 AG015473NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG054023NIA NIH HHS RF1 AG054047NIA NIH HHS RF1 AG054080NIA NIH HHS RF1 AG058501NIA NIH HHS T32 AG071444NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG052410NIA NIH HHS U01 AG058922NIA NIH HHS U01 AG068057NIA NIH HHS U01 AG072177NIA NIH HHS U19 AG024904NIA NIH HHS U19 AG066567NIA NIH HHS U19 AG074879NIA NIH HHS U19 AG078109NIA NIH HHS U24 AG041689NIA NIH HHS U24 AG056270NIA NIH HHS U24 AG067418NIA NIH HHS U24 AG072122NIA NIH HHS U24 AG074855NIBIB NIH HHS P41 EB015922NIH HHS DP2AG082342NIH HHS P30-AG010133NIH HHS P30-AG072976NIH HHS R00-AG061238NIH HHS R01-AG019771NIH HHS R01-AG029672NIH HHS R01-AG057739NIH HHS R01-AG061028NIH HHS R01-AG062826NIH HHS R01-AG068193NIH HHS R01-AG073439NIH HHS R01-AG079142NIH HHS R01-AG082730NIH HHS R01-LM013463NIH HHS T32-AG071444NIH HHS U01-AG0006781NIH HHS U01-AG068057NIH HHS U01-AG072177NIH HHS U19-AG024904NIH HHS U19-AG066567NIH HHS U19-AG074879NIH HHS U24-AG074855NLM NIH HHS R01 LM013463
6 · The paper itself

Abstract

introductionAccurately assessing the temporal order of cognitive decline across multiple domains is critical in Alzheimer's disease (AD). Existing literature presents controversial conclusions likely due to the use of a single cohort and different analytical strategies.

methodsHarmonized composite cognitive measures in memory, language, and executive functions from 13 cohorts in the Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) were used. A double anchoring events-based sigmoidal mixed model was developed using time to incident AD diagnosis as the time scale.

resultsIn general, decline in memory occurred before decline in language, followed by decline in executive function. This temporal order generally persisted within each subgroup of apolipoprotein E ε4 carrier status, sex, and race/ethnicity. DISCUSSION: This study demonstrated the use of harmonized data across multiple cohorts to characterize the temporal order of cognitive decline along AD progression. Using time to incident AD diagnosis as the time scale can enhance research reproducibility and clinical practice. HIGHLIGHTS: Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortium's harmonized composite cognitive measures from 13 cohort studies fitted with a novel double anchoring event-based sigmoidal mixed model reveal the following temporal order of cognitive decline toward AD progression: memory, language, and executive function. If only investigated using individual cohort studies, the temporal order of cognitive decline would vary due to the underlying heterogeneities across studies. This temporal order generally persisted within each subgroup of apolipoprotein E ε4 carrier status, sex, and race/ethnicity.

Indexed as

Alzheimer DiseaseCognitive DysfunctionDisease ProgressionAgedAged, 80 and overApolipoprotein E4Cohort StudiesExecutive FunctionFemaleHumansMaleNeuropsychological TestsApolipoprotein E4Alzheimer's Disease Sequencing Project Phenotype Harmonization Consortiumcognitive declineharmonized composite measuressigmoidal mixed modeltemporal order

Identifiers

PMID40538025
PMCPMC12179338

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.