ArticleJournal of gynecologic oncology2025
Global burden of uterine cancer in 204 countries and territories and its predicted level in 15 years, from 1990 to 2021.
Article in Journal of gynecologic oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Molecular classification and association with survival outcomes in high-intermediate and high-risk early-stage endometrial cancers: Ancillary analysis of GOG-0249.Gynecologic oncology · 2026Trial
- Temporal Trends in Mortality of Female Cancers Among Women and the Impact of COVID-19 in Low- and Middle-Income Countries, 1990-2023: An Age-Period-Cohort Analysis from the Global Burden of Disease Study 2023.International journal of women's health · 2026Article
- The association between metabolic syndrome and incidence of endometrial cancer: a meta-analysis.Diabetology & metabolic syndrome · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveUterine cancer (UC) is a major cause of cancer-related deaths among women. This study assesses the global burden of UC from 1990 to 2021.
methodsData from the Global Burden of Disease 2021 study were used to analyze UC incidence, mortality, and disability-adjusted life years (DALYs) across 204 countries. Age-standardized rates were evaluated by age and Socio-Demographic Index (SDI), with trends forecasted to 2036 using Bayesian models.
resultsIn 2021, the global incidence of UC reached 473,614 cases (95% uncertainty interval [UI]=4,29916-5,13667), with an age-standardized incidence rate of 5.41 per 100,000 (95% UI=4.90-5.87), showing an upward trend since 1990, particularly in high-SDI regions. However, the mortality rate in high SDI regions exhibited a declining trend, with an estimated annual percentage change (EAPC) of -0.25 (95% confidence interval=-0.42 to -0.08). Although the number of deaths globally has increased, the age-standardized mortality rate has decreased compared to 1990 (EAPC: -0.85). The global age-standardized DALYs also show a downward trend, except in high SDI and low-middle SDI regions. The highest incidence was observed among individuals aged 70-74 in 2021. By 2036, new cases are projected to rise, though incidence, mortality, and DALYs are expected to decline.
conclusionRegional disparities in the global UC burden highlight the need for tailored strategies, especially in low-income countries, to reduce its impact.
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