ArticleEuropean journal of medical research2025
Unveiling the genetic association between rheumatoid arthritis and four common hand pathologies.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Efficacy of Subcutaneous Kenacort Injection for Trigger Finger: A Retrospective Analysis.Plastic and reconstructive surgery. Global open · 2026Article
- Trigger finger and the risk of systemic inflammatory and autoimmune rheumatic diseases: real-world evidence.Frontiers in immunology · 2026Article
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Authors and funding
4 authors.
Funding
Abstract
backgroundRheumatoid arthritis (RA), carpal tunnel syndrome (CTS), trigger finger (TF), Dupuytren's disease (DD) and de Quervain tenosynovitis (DQT) are musculoskeletal disorders that affect hand abilities. Previous studies have suggested inconsistent results on their association. This study aims to determine the cause-and-effect relationship between RA and other four hand disorders.
methodsWe collected summary-level statistics for RA, CTS, TF, DD, and DQT from genome-wide association studies (GWAS). A univariable Mendelian randomization (UVMR) analysis was conducted to investigate the cause-and-effect relationship between RA and other hand conditions. Furthermore, a multivariable Mendelian randomization (MVMR) analysis was conducted to evaluate the influence of confounding variables such as glycemia, obesity, and lifestyle factors on this causal association. The robustness of our findings is assessed by a series of sensitivity analyses at the end.
resultsThe inverse variance-weighted method in UVMR revealed that genetically predicted RA was positively associated with risks of CTS (OR = 04, 95% CI 1.01-1.07, P = 4.97E-03), TF (OR = 1.13, 95% CI 1.06-1.20, P = 8.97E-05), and DQT (OR = 1.11, 95% CI 1.02-1.21, P = 0.019), but not linked with DD (OR = 1.01, 95% CI = 0.96-1.07, P = 0.61). After adjusting for glycemia, obesity, and lifestyle factors in the MVMR analyses, the causal effects of RA on increased risks of CTS and TF remained significant. Leave-one-out analyses demonstrated that no individual single nucleotide polymorphism (SNP) significantly impacted RA's overall causal effect estimates on CTS and TF.
conclusionsOur results indicate that RA is an independent genetic factor contributing to CTS and TF, but not to DQT or DD. This finding supports recommendations aimed at preventing the occurrence of CTS and TF in patients with RA. However, further high-quality studies are needed to validate this association and to determine its general applicability.
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