ArticleEuropean journal of medical research2025
Outcomes and risk factors in HIV-positive patients with sepsis: a retrospective study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Corticosteroids in immunocompromised ICU patients with pneumonia: risks, evidence, and clinical practice.Pneumonia (Nathan Qld.) · 2026Review
- Development and validation of a 28-day mortality risk prediction model for patients with AIDS suffering from sepsis secondary to pulmonary infections in the ICU.BMC infectious diseases · 2026Article
- Impact of maternal HIV infection on pregnancy and labor complication and perinatal health outcomes: a South African retrospective study.Archives of gynecology and obstetrics · 2026Article
- Sepsis in multimorbidity: a domain-based framework for systemic vulnerability and precision care.Frontiers in medicine · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
purposeThe aim of this study was to assess the outcomes and risk factors for in-hospital mortality and further explore a predictive model for forecasting in-hospital mortality in HIV-positive patients with sepsis.
methodsA retrospective cohort study of 203 hospitalized HIV-positive patients with sepsis was conducted at Chongqing Public Health Medical Center, a tertiary-level infectious disease hospital, from January 2021 to December 2023. Patients were divided into two groups according to survival status (survival and death). The patients' baseline characteristics, laboratory findings and outcomes were collected for comprehensive analysis.
resultsThe in-hospital mortality rate was 18.7%. Independent risk factors for in-hospital mortality in HIV-positive patients with sepsis were acute respiratory failure (OR 3.654, 95% CI 1.303-10.248, p = 0.014), septic shock (OR 9.542, 95% CI 3.614-25.197, p < 0.001), chronic liver disease (OR 4.330, 95% CI 1.348-13.910, p = 0.014) and lactate (OR 1.570, 95% CI 1.195-2.062, p = 0.001). The AUC for the RF model to predict in-hospital death was 0.853, and the threshold was -1.553 with a sensitivity of 73.7% and a specificity of 84.8%.
conclusionsAcute respiratory failure, septic shock, chronic liver disease and lactate were independent risk factors for in-hospital mortality in HIV-positive patients with sepsis. The prediction model based on these four risk factors demonstrated good effectiveness in predicting in-hospital mortality among HIV-positive patients with sepsis.
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