Evidence map›Paper›PMID 40537820›Full record

ArticleArchives of public health = Archives belges de sante publique2025

Is there a relationship between the route of HIV transmission and cognitive performance in older individuals living with HIV?

Francesco Salis, Maristella Belfiori, Francesco Ortu, Paola Piano, Stefano Del Giacco, Antonella Mandas

Erratum issuedAbstract read
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Francesco SalisDepartment of Medical Sciences, and Public Health, University of Cagliari, Cagliari, Italy. francesco-salis@tiscali.it.
Maristella Belfiori *Department of Medical Sciences, and Public Health, University of Cagliari, Cagliari, Italy.
Francesco OrtuUniversity Hospital "Azienda Ospedaliero-Universitaria" of Cagliari, Cagliari, Italy.
Paola PianoUniversity Hospital "Azienda Ospedaliero-Universitaria" of Cagliari, Cagliari, Italy.
Stefano Del GiaccoDepartment of Medical Sciences, and Public Health, University of Cagliari, Cagliari, Italy.
Antonella MandasDepartment of Medical Sciences, and Public Health, University of Cagliari, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background- HIV-related neurocognitive disorders are a growing public health issue, especially in older people living with HIV/AIDS (PLWHA). The aim of this study is to evaluate the relationship between cognitive performance and route of HIV transmission in an older group of PLWHA.

methods- In this cross-sectional study, conducted between November 2022 and July 2023, we enrolled PLWHA aged 50 years or older, treated with highly active anti-retroviral therapy, and with a low/undetectable viral load. Cognitive assessment was performed with HIV Dementia Scale.

resultsIn total, 268 subjects were enrolled. Cognitive impairment was present in 20.9% of the participants. According to a logistic model, people who contracted HIV through sexual transmission had 74% lower odds of cognitive impairment compared to those who contracted HIV through intravenous substance use (OR: 0.26, 95%CI 0.12-0.56). The adjustment for confounders confirmed lower odds for sexual transmission (OR: 0.27, 95%CI 0.12-0.60).

conclusionsThe route of HIV transmission is potentially associated with cognitive impairment in PLWHA, with patients infected via intravenous substance use being at higher risk.

Indexed as

Cognitive statusEarly agingHANDHIVSubstance useTransmission

Identifiers

PMID40537820
PMCPMC12178064

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.