Evidence map›Paper›PMID 40537758›Full record

ArticleBMC biotechnology2025

Newly designed curcumin-loaded hybrid nanoparticles: a multifunctional strategy for combating oxidative stress, inflammation, and infections to accelerate wound healing and tissue regeneration.

Heidi M Abdel-Mageed, Nermeen Z AbuelEzz, Ahmed A Ali, Amira Emad Abdelaziz, Dina Nada, Sahar M Abdelraouf, Shahinaze A Fouad, Abeer Bishr, Rasha A Radwan

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In one paragraph

Article in BMC biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Heidi M Abdel-MageedMolecular Biology Department, National Research Centre, Dokki, Giza, Egypt. heidi.abdelmageed@gmail.com.
Nermeen Z AbuelEzzBiochemistry Department, College of Pharmaceutical Sciences and Drug Manufacturing, Misr University for Science and Technology, Cairo, Egypt.
Ahmed A AliMolecular Biology Department, National Research Centre, Dokki, Giza, Egypt.
Amira Emad AbdelazizPharmacology Department, Clinical and Biological Sciences Departments, College of Pharmacy, Arab Academy for Science and Technology and Maritime Transport, Abu Kir, Alexandria, Egypt.
Dina NadaPharmacology and Biochemistry Department, Faculty of Pharmacy, The British University in Egypt (BUE), Cairo, Egypt.
Sahar M AbdelraoufDepartment of Biochemistry, Faculty of Pharmacy, Misr International University (MIU), Cairo, Egypt.
Shahinaze A FouadDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
Abeer BishrPharmacology and Toxicology Department, Faculty of Pharmacy, Ahram Canadian University, Giza, Egypt.
Rasha A RadwanBiochemistry Department, Faculty of Biotechnology, German International University, Regional Ring Rd, East Cairo, New Administrative Capital, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective treatment of skin wounds remains a clinical challenge owing to factors such as microbial infections, impaired fibroblast activity, disrupted angiogenesis, and collagen remodeling. In this study, we developed and evaluated novel curcumin-cyclodextrin hybrid nanoparticles (Cur/CD-HNPs) as a multifunctional platform for enhanced wound healing. Nanoparticles (NPs) were prepared via nanoprecipitation. Physicochemical and structural properties were systematically characterized by determining the encapsulation efficiency (EE), particle size, zeta potential, X-XRD, FTIR, SEM, in vitro release, and stability studies. The optimized Cur/CD-HNPs demonstrated a uniform particle size of 150.5 ± 2.8 nm, a surface charge of - 18.5 ± 0.59 mV, a PDI of 0.20 ± 0.03, and a high EE (90.2 ± 2.35%). Cur/CD-HNPs exhibited potent anti-inflammatory effects (97.93 ± 1.24% inhibition of protein denaturation), full antioxidant activity (100% ABTS radical scavenging, IC50 = 12.85 µg/mL), and broad-spectrum antibacterial efficacy. Cur/CD-HNPs exhibited a sustained biphasic release profile, with ~ 82% of Cur released over 24 h, supporting sustained delivery for wound healing applications. In vitro scratch assays revealed enhanced fibroblast proliferation and migration. For in vivo evaluation, the nanoparticles were incorporated into a hydrogel base and applied topically in a rat burn wound model, resulting in significantly accelerated wound closure (P < 0.05). Histopathological examination revealed improved epithelialization, collagen deposition, and tissue regeneration compared with the control groups. Our findings presented Cur/CD-HNPs as a promising therapeutic approach, offering Cur enhanced bioactivity, stability, and regenerative potential. This formulation addresses the key limitations of curcumin and presents a multifunctional and strong translational platform for clinical wound care.

Indexed as

CurcuminNanoparticlesOxidative StressWound HealingAnimalsAnti-Bacterial AgentsAntioxidantsHumansInflammationMaleParticle SizeRatsRats, Sprague-DawleyRegenerationAnti-Bacterial AgentsAntioxidantsCurcuminAntioxidant anti-inflammatoryCurcuminCyclodextrinHybrid nanoparticlesHydrogelsTissue regenerationWound healing

Identifiers

PMID40537758
PMCPMC12180217

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.