ArticleBMC medical imaging2025
Diffusion weighted imaging-based differentiation of arteritic and non-arteritic anterior ischemic optic neuropathy.
Article in BMC medical imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Vasculitis syndromes: large vessel vasculitides and ANCA-associated vasculitides from a neuroradiologist's perspective.Japanese journal of radiology · 2026Review
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7 authors.
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Abstract
purposeTo assess the utility of DWI-MRI to differentiate arteritic (A-AION) from non-arteritic (NA-AION) ischemic optic neuropathy.
methodsThis bicentric cohort-study evaluated 3T DWI-MRI scans performed within 10 days after onset of AION in patients treated between 2014 and 2024 at two tertiary care centers. DWI was first assessed for the presence of restricted diffusion within the optic nerve. Quantitative apparent diffusion coefficient (ADC) evaluation was performed by placing a region of interest (ROI) within the affected optic nerve. Qualitative and quantitative DWI assessments were compared between A-AION and NA-AION patients.
resultsTwenty A-AION patients (75.7 ± 6.8 years; 16 [80.0%] female) and 59 NA-AION patients (64.6 ± 10.7 years; 22 [37.3%] female) with a total of 82 (A-AION: 23; NA-AION: 59) DWI-MRI scans were included in the study. Restricted diffusion on ADC was significantly more frequent in A-AION, when compared to NA-AION (82.6% vs. 42.4%; p = 0.001). Corresponding sensitivity, specificity, positive and negative predictive value of qualitative ADC assessment for the identification of A-AION were 0.83, 0.58, 0.43 and 0.89. Quantitative ADC analysis revealed significantly lower values in optic nerves affected by A-AION (ADC: 448.0 ± 256.2 × 10
conclusionRestricted diffusion of the optic nerve is more frequent in A-AION and associated with lower optic nerve ADC values, when compared to NA-AION. Prospective studies are required to further explore the potential of DWI in discerning arteritic from non-arteritic AION.
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