Evidence map›Paper›PMID 40537739›Full record

ArticleLipids in health and disease2025

Triglyceride-glucose index and its related factors may be predictors for cardiovascular disease among Chinese postmenopausal women: a 12-year cohort study.

Weiyan Tu, Rongdi Xu, Dan Wang, Na Luo, Meijing Wu, Yong Zhou, Jing Ning

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. [A Study of the Association and Interaction Between Organophosphorus Pesticide Exposure and Insulin Resistance in Non-diabetic Adults].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  5. Article
  6. Article
  7. Observational
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weiyan Tu *Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, No. 2699, West Gaoke Road, Shanghai, 200092, China.
Rongdi Xu *Clinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China.
Dan WangHainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, NO.339 Yingbin Road, Sanya, 572022, China.
Na LuoHainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, NO.339 Yingbin Road, Sanya, 572022, China.
Meijing WuHainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, NO.339 Yingbin Road, Sanya, 572022, China.
Yong ZhouClinical Research Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, No.85 Wujin Road, Shanghai, 200080, China. yongzhou78214@163.com.
Jing NingHainan Branch, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, NO.339 Yingbin Road, Sanya, 572022, China. ningjing8874@sina.com.

Funding

National Key Research and Development Program of China 2021YFC2500500National Natural Science Foundation of China U22A20364, 92049302
6 · The paper itself

Abstract

backgroundThis study investigated and compared the abilities of the triglyceride glucose index (TyG) and its correlated factors involving TyG-body mass index (TyG-BMI), TyG-waist-to-height ratio (TyG-WHtR), and TyG-waist circumference (TyG-WC) to predict cardiovascular disease (CVD) among Chinese postmenopausal women. This topic has not been adequately explored in the existing literature.

methodsThis prospective study included 1110 Chinese postmenopausal women, stratified into the CVD group and the non-CVD group. The TyG index and its correlated components (TyG, TyG-BMI, TyG-WHtR, and TyG-WC) were calculated. The primary endpoint was CVD.

resultsAcross a 12-year follow-up period, 76 (6.84%) CVDs were documented. The TyG index, in collaboration with various indicators of obesity, demonstrated a robust positive correlation with the risk of CVD. In comparison to other TyG indices, TyG-WC was the strongest predictor for CVD (HR: 2.61, 95%CI:1.64-4.14; P < 0.001), and the TyG-WHtR index exhibited the strongest diagnostic value in identifying CVD (AUC: 0.632, 95%CI: 0.603-0.660; P < 0.001). Incorporating TyG-WHtR into the base model significantly enhanced incremental risk stratification for CVD (NRI: 0.115, 95%CI: 0.040-0.190, P < 0.05; AIC: 996; BIC: 1041; Harrell's C-index: 0.73). Decision curve analysis (DCA) suggested that TyG, TyG-WHtR, and TyG-WC can provide significant clinical benefits for Chinese postmenopausal women. The sensitivity analyses have demonstrated the robustness of these results.

conclusionsThe TyG index and its correlated factors can effectively predict CVD in Chinese postmenopausal women. TyG-WHtR has the most potent ability to predict CVD among postmenopausal women.

Indexed as

Blood GlucoseCardiovascular DiseasesPostmenopauseTriglyceridesAgedBody Mass IndexChinaEast Asian PeopleFemaleHumansMiddle AgedProspective StudiesRisk FactorsWaist CircumferenceBlood GlucoseTriglyceridesCardiovascular diseasePostmenopausal womenProspective studyThe TyG-BMI indexThe TyG indexThe TyG-WC indexThe TyG WHtR index

Identifiers

PMID40537739
PMCPMC12180246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.