ArticleBMC plant biology2025
Comparative transcriptome analysis reveals candidate gene for flowering time QTL HvHeading in barley.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Genome-Wide Characterization of Genetic Diversity and Population Structure in a Kazakhstani Two-Row Spring Barley Breeding Panel.International journal of molecular sciences · 2026Article
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4 authors.
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Abstract
backgroundIdentifying genes regulating flowering time enhances understanding mechanisms that improve crop adaptation and productivity. This study aims to identify gene(s) underlying barley flowering time quantitative trait locus (QTL) "HvHeading".
resultsTo investigate the reported delayed-flowering effect of QTL, we selected spring barley MAGIC DH lines with different alleles in HvHeading locus which carry the same alleles in epistatic loci. Phenotyping apex development revealed contrasting effects of two alleles of HvHeading locus. Combining recombination and differential gene expression analyses using RNA-sequencing for apex and leaf tissue pinpointed a 3.94 Mbs interval which carried 22 differently expressed genes. Initial analysis using Morex IBSC v2 reference genome suggested a transcription elongation factor HvSpt6, encoded by HORVU1Hr1G067820, as a possible candidate gene potentially involved in flowering time regulation. Full-length HvSpt6 sequencing found two promoter mutations in the allele from delayed-flowering genotype, creating a binding site for TEM1, a transcription factor known for involvement in suppressing flowering time in Arabidopsis.
conclusionsThe findings provided the first insights for flowering time regulation by HvHeading underlying gene. Though further functional studies are needed to conclusively identify the causal gene. This study showed that leveraging knowledge of epistatic loci to address phenotypic background effects, followed by RNA sequencing can be an effective approach for identifying genes in large regions of suppressed recombination in crops with complex genomes.
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