Evidence map›Paper›PMID 40537727›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2025

Can intraoperative sentinel node fine-needle aspiration biopsy replace sentinel node biopsy in early-stage breast cancer patients undergoing breast-conserving surgery?

I Barco, A García, E Vallejo, M Torras, X Tarroch, M Ysamat, M Fraile

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

I BarcoBreast Unit, Department of Gynecology, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain. ibarco@mutuaterrassa.es.ORCID http://orcid.org/0000-0003-3520-8736
A GarcíaBreast Unit, Department of Gynecology, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain.
E VallejoBreast Unit, Department of Gynecology, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain.
M TorrasBreast Unit, Department of Gynecology, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain.
X TarrochBreast Unit, Department of Gynecology, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain.
M YsamatBreast Unit, Department of Gynecology, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain.
M FraileBreast Unit, Department of Gynecology, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSentinel Node Biopsy (SNB) side effects could be avoided if the sentinel node (SN) is sampled but not removed using intraoperative fine-needle aspiration biopsy (FNAB). In a previous study, we demonstrated the feasibility of this technique. The goal of our current research is to evaluate its potential as an alternative to SNB in node-negative patients undergoing breast-conserving surgery. PATIENTS AND

methodsWe studied 153 cases referred to our Breast Unit for treatment involving conservative breast surgery and SNB. Patients receiving neoadjuvant chemotherapy were excluded. We assessed the sensitivity, specificity, and negative predictive value (NPV) of intraoperative SN-FNAB by comparing it with histopathology results and the need for subsequent axillary lymph node dissection (ALND) across three levels of analysis: direct pathologic comparison, exclusion of micrometastases, and exclusion of up to two involved sentinel nodes.

resultsIn 81.7% of cases, samples were suitable for cytologic analysis. Both sensitivity and NPV reached 100% in the third level of analysis. No negative cases showed tumor involvement beyond the sentinel node. Positive FNAB results were associated with a higher likelihood of ALND and greater axillary tumor burden.

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastMastectomy, SegmentalSentinel Lymph NodeSentinel Lymph Node BiopsyAdultAgedAged, 80 and overAxillaBiopsy, Fine-NeedleFemaleHumansLymphatic MetastasisLymph Node ExcisionMiddle AgedNeoplasm StagingFine-needle aspiration biopsyLymphatic metastasisLymph-node excisionSentinel node biopsy

Identifiers

PMID40537727

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.