ArticleAnnals of surgical oncology2025
Comparison of Partial Nephrectomy Versus Radical Nephrectomy for Metastatic Renal Cell Carcinoma in the Immunotherapy Era: A Propensity Score Matching, Population-Based Analysis.
Article in Annals of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Application of three-dimensional reconstruction combined with enhanced recovery after surgery in patients undergoing laparoscopic partial nephrectomy: a prospective observational study.BMC nephrology · 2026Observational
- Review
- Clinicopathological features and prognostic factors of clear cell papillary renal cell tumor: a retrospective population-based analysis.Translational andrology and urology · 2025Article
- Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundThe therapeutic paradigm for metastatic renal cell carcinoma (mRCC) has experienced a transformative evolution, and cytoreductive nephrectomy remains a clinically viable option in the immunotherapy era. However, the survival benefits of partial nephrectomy (PN) and radical nephrectomy (RN) have yet to be compared. This study aimed to comprehensively compare the outcomes of PN and RN among patients with mRCC in the real-world setting. PATIENTS AND
methodsThe Surveillance, Epidemiology, and End Results (SEER) database was reviewed for patients with mRCC diagnosed between 2016 and 2021 who underwent PN or RN. The endpoints were overall survival (OS), disease-specific survival (DSS), and other-cause specific survival (OCSS). The analytical methods included propensity score matching (PSM), Kaplan‒Meier survival curves, and Cox proportional hazards modeling.
resultsA total of 2775 patients with mRCC were identified, with 134 (4.8%) undergoing PN and 2641 (95.2%) receiving RN. Patients in the PN group were more frequently diagnosed with lower T stage, lower grade, N0, and non-clear cell RCC, whereas those in the RN group exhibited a higher incidence of lung metastasis. Following 1:2 PSM, there was no significant difference in OS, DSS, and OCSS between the groups. Further subgroup analysis indicated that PN may contribute to prolonged OS in patients with mRCC with T1 and N0 disease, whereas patients with N1 mRCC may benefit more from RN.
conclusionsPN could provide comparable survival benefit as RN for patients with mRCC in the era of immunotherapy. However, preoperative staging and risk stratification are necessary, as the prognosis of mRCC varied between groups with different T or N stages.
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