Article in The EMBO journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Yiting Gao *Department of Pharmacology; The Key Laboratory of New Drug Pharmacology and Toxicology; The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Hebei Collaboration and Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Diseases, Hebei Medical University, Shijiazhuang, Hebei, China.
Shengxiang Yan *Department of Pharmacology; The Key Laboratory of New Drug Pharmacology and Toxicology; The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Hebei Collaboration and Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Diseases, Hebei Medical University, Shijiazhuang, Hebei, China.ORCID http://orcid.org/0009-0002-6771-5097
Zhongyang ZhangDepartment of Pharmacology; The Key Laboratory of New Drug Pharmacology and Toxicology; The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Hebei Collaboration and Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Diseases, Hebei Medical University, Shijiazhuang, Hebei, China.
Jieyao ZhangDepartment of Pharmacology; The Key Laboratory of New Drug Pharmacology and Toxicology; The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Hebei Collaboration and Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Diseases, Hebei Medical University, Shijiazhuang, Hebei, China.
Meng YangDepartment of Pharmacology; The Key Laboratory of New Drug Pharmacology and Toxicology; The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Hebei Collaboration and Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Diseases, Hebei Medical University, Shijiazhuang, Hebei, China.
Shihab ShahSchool of Biomedical Sciences; Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Sofia FigoliSchool of Biomedical Sciences; Faculty of Biological Sciences, University of Leeds, Leeds, UK.
Haixia GaoDepartment of Pharmacology; The Key Laboratory of New Drug Pharmacology and Toxicology; The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Hebei Collaboration and Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Diseases, Hebei Medical University, Shijiazhuang, Hebei, China. gaohx686@hebmu.edu.cn.ORCID http://orcid.org/0009-0008-2196-4403
Nikita GamperDepartment of Pharmacology; The Key Laboratory of New Drug Pharmacology and Toxicology; The Key Laboratory of Neural and Vascular Biology, Ministry of Education; The Hebei Collaboration and Innovation Center for Mechanism, Diagnosis and Treatment of Neurological and Psychiatric Diseases, Hebei Medical University, Shijiazhuang, Hebei, China. n.gamper@leeds.ac.uk.ORCID http://orcid.org/0000-0001-5806-0207
Funding
Central Guiding Local Science and Technology Development Fund 236Z7723GEC | Horizon 2020 Framework Programme (H2020) 956477Hebei Natural Science Foundation H2022206515Key laboratory of Neural and Vascular Biology, Ministry of Education of China NV20230001MOST | National Natural Science Foundation of China (NSFC) 81871027UKRI | MRC | Medical Research Council Centre for Medical Mycology (MRC CMM) MR/V012738/1Wellcome TrustWellcome Trust (WT) 212302/Z/18/Z
6 · The paper itself
Abstract
Copine-6 is a calcium-sensitive phospholipid-binding protein of the evolutionarily conserved Copine family. In the central nervous system, Copine-6 regulates function of some neurotransmitter receptors and structural plasticity of dendritic spines, influencing learning and memory. Copine-6 is expressed in peripheral somatosensory neurons, but its role in somatosensation remains unclear. Here we demonstrate that Copine-6 plays a prominent role in thermosensation. Copine-6 is highly expressed in a subpopulation of dorsal root ganglia (DRG) neurons that also express thermosensitive TRPM3 channels. Genetic deletion or downregulation of Copine-6 in the DRG in vivo selectively impairs sensitivity to noxious heat, without affecting other sensory modalities, and significantly reduced TRPM3 currents in DRG neurons. Copine-6 interacts with TRPM3 via its von Willebrand factor A (vWA) domain, promoting TRPM3 translocation to the plasma membrane. Thus, Copine-6-dependent TRPM3 trafficking determines noxious-heat sensitivity range of the nerve fibers; moreover, Copine-6 is an accessible target for the treatment of heat hypersensitivity in chronic inflammatory and neuropathic pain.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Copine-6 is a TRPM3 escort protein controlling the sensitivity of sensory neurons to noxious heat. · full record | OpenQuestion