Evidence map›Paper›PMID 40537553›Full record

ArticleNature cell biology2025

Crossover patterning through condensation and coarsening of pro-crossover factors.

Liangyu Zhang, Weston Stauffer, Chenshu Liu, Hengyi Shao, Noor Abuzahriyeh, Rui Jiang, David Zwicker, Xing Liu, Xuebiao Yao, Abby F Dernburg

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Structure and function of the synaptonemal complex.The Journal of cell biology · 2026
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Multi-step implementation of meiotic crossover patterning.bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. The synaptonemal complex aligns meiotic chromosomes by wetting.bioRxiv : the preprint server for biology · 2024
    Article
  19. Review
  20. A suppressor screenbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liangyu Zhang *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. lyzhang0@mail.ustc.edu.cn.ORCID http://orcid.org/0000-0002-2701-0773
Weston Stauffer *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Chenshu Liu *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-4538-5728
Hengyi Shao *Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.
Noor AbuzahriyehDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0009-0004-5120-0843
Rui JiangDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID http://orcid.org/0000-0001-6000-8512
David ZwickerMax Planck Institute for Dynamics and Self-Organization, Göttingen, Germany.ORCID http://orcid.org/0000-0002-3909-3334
Xing LiuMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China.ORCID http://orcid.org/0000-0002-7480-5085
Xuebiao YaoMOE Key Laboratory for Membraneless Organelles and Cellular Dynamics, Hefei National Research Center for Physical Sciences at the Microscale, University of Science and Technology of China, Hefei, China. yaoxb@ustc.edu.cn.ORCID http://orcid.org/0000-0001-8982-5911
Abby F DernburgDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA. afdernburg@berkeley.edu.ORCID http://orcid.org/0000-0001-8037-1079

Funding

National Natural Science Foundation of China (National Science Foundation of China) 2022YFA1303100National Natural Science Foundation of China (National Science Foundation of China) 32090040
6 · The paper itself

Abstract

Meiotic recombination mixes genetic information from parental genomes, creating unique combinations of alleles. During meiotic prophase, each homologue pair must undergo at least one crossover to segregate faithfully. Only a few recombination intermediates become crossovers, and these are widely spaced or limited to one per chromosome pair. Mechanisms that regulate crossover number and spacing remain poorly understood. Here we show that, in Caenorhabditis elegans, 'recombination nodules', protein assemblies that stabilize recombination intermediates and promote crossover formation, assemble in part through biomolecular condensation and are stabilized by CDK-2 kinase activity. We further demonstrate that essential components of these nodules move along the synaptonemal complex (SC) and do not freely exchange between SCs in the same nucleus. Our findings reveal that recombination nodules behave as active droplets and support a model in which coarsening of these droplets via protein translocation along liquid crystalline SCs underlies crossover patterning.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsCrossing Over, GeneticMeiosisAnimalsSynaptonemal ComplexCaenorhabditis elegans Proteins

Identifiers

PMID40537553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.