Evidence map›Paper›PMID 40537538›Full record

ArticlePediatric research2026

Physiological differences in cardiopulmonary exercise testing between children and adults.

Valentina Papic, Romina Ledergerber, Ralf Roth, Raphael Knaier

Abstract readComparative Study
In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Valentina Papic *Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Romina Ledergerber *Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland. romina.ledergerber@unibas.ch.ORCID http://orcid.org/0000-0003-1505-1188
Ralf RothDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.
Raphael KnaierDepartment of Sport, Exercise and Health, University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPhysiological responses to exercise differ between children and adults, but achieving maximal exertion in children complicates the interpretation of VO

methodsIn this cross-sectional study, 24 children (7-11 years), 20 moderately trained adults (MTA), and 20 well-trained adults (WTA; 20-30 years) completed a maximal incremental exercise test on a cycle ergometer with continuous respiratory measurement. Linear regression models analysed age and sex differences in ventilatory thresholds (VT1, VT2) and oxygen uptake efficiency slope and plateau (OUES), with Cohen's d effect sizes reported.

resultsChildren showed higher body mass-adjusted VO

conclusionsChildren rely more on oxidative metabolism than adults. Maturation influences exercise efficiency more than body mass, underscoring physiological differences. These age- and sex-specific patterns call for longitudinal studies to further explore the roles of growth and training. IMPACT: This study identifies clear physiological differences in submaximal CPET parameters between children and adults. It adds novel insight by including both ventilatory thresholds and oxygen uptake efficiency, adjusted for body mass and training status. The findings suggest children rely more on oxidative metabolism, emphasizing the importance of maturation on exercise efficiency and informing age- and sex-specific assessment protocols in pediatric exercise physiology.

Indexed as

ExerciseExercise TestAdultAge FactorsChildCross-Sectional StudiesFemaleHumansMaleOxygen ConsumptionSex FactorsYoung Adult

Identifiers

PMID40537538
PMCPMC12956600

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.