Evidence map›Paper›PMID 40537510›Full record

ArticleNature immunology2025

Neuroprotective liver portal area macrophages attenuate hepatic inflammation.

Mengli Xu, Zheng Liu, Qi Pan, Zhenzhen Cai, Xinlin Li, Songlin Huang, Xinru Wang, Yilun Xu, Jiayang Liu, Yujie Zhai and 8 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. The hepatic portal area in homeostasis and disease.Clinical and molecular hepatology · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mengli Xu *School of Life and Health Sciences, Institute of Biomedical Research, Hainan Province Key Laboratory of One Health, Hainan University, Haikou, China.
Zheng Liu *School of Life and Health Sciences, Institute of Biomedical Research, Hainan Province Key Laboratory of One Health, Hainan University, Haikou, China. liu-zheng@hainanu.edu.cn.ORCID http://orcid.org/0000-0002-2348-8163
Qi PanSchool of Life and Health Sciences, Institute of Biomedical Research, Hainan Province Key Laboratory of One Health, Hainan University, Haikou, China.
Zhenzhen CaiState Key Laboratory of Digital Medical Engineering, Britton Chance Center for Biomedical Photonics, School of Biomedical Engineering, Hainan University, Sanya, China.
Xinlin LiMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.
Songlin HuangSchool of Life and Health Sciences, Institute of Biomedical Research, Hainan Province Key Laboratory of One Health, Hainan University, Haikou, China.
Xinru WangMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0009-0003-6183-1852
Yilun XuState Key Laboratory of Digital Medical Engineering, Britton Chance Center for Biomedical Photonics, School of Biomedical Engineering, Hainan University, Sanya, China.
Jiayang LiuState Key Laboratory of Digital Medical Engineering, Britton Chance Center for Biomedical Photonics, School of Biomedical Engineering, Hainan University, Sanya, China.
Yujie ZhaiMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.
Jie YangMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0003-4346-9100
Borui LiMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.
Zhan FanSchool of Life and Health Sciences, Institute of Biomedical Research, Hainan Province Key Laboratory of One Health, Hainan University, Haikou, China.
Yafang LuMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.
Lulu GaoMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.
Yutong HanMoE Key Laboratory for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, China.
Qingming LuoState Key Laboratory of Digital Medical Engineering, Britton Chance Center for Biomedical Photonics, School of Biomedical Engineering, Hainan University, Sanya, China. qluo@hainanu.edu.cn.ORCID http://orcid.org/0000-0002-6725-9311
Zhihong ZhangSchool of Life and Health Sciences, Institute of Biomedical Research, Hainan Province Key Laboratory of One Health, Hainan University, Haikou, China. zhzhang@hainanu.edu.cn.ORCID http://orcid.org/0000-0001-5227-8926

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32330048
6 · The paper itself

Abstract

Tissue macrophages have an important role in the maintenance of liver homeostasis, and their functions are closely related to spatial localization. Here, through integration of whole liver lobe imaging and single-cell RNA sequencing analysis of CX3CR1

Indexed as

LiverMacrophagesNon-alcoholic Fatty Liver DiseaseAnimalsCX3C Chemokine Receptor 1HepatocytesHomeostasisInflammationMaleMiceMice, Inbred C57BLMice, KnockoutNeutrophil InfiltrationReceptors, Granulocyte-Macrophage Colony-Stimulating FactorSympathetic Nervous SystemCsf1r protein, mouseCX3C Chemokine Receptor 1Cx3cr1 protein, mouseReceptors, Granulocyte-Macrophage Colony-Stimulating Factor

Identifiers

PMID40537510

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.