Evidence map›Paper›PMID 40537507›Full record

ArticleBone marrow transplantation2025

Impact of fludarabine dose on outcome after allo-HSCT with reduced intensity conditioning for older patients with AML.

Guillaume Dachy, Myriam Labopin, Gérard Socié, Cristina Castilla-Llorente, Edouard Forcade, Igor Wolfgang Blau, Patrice Ceballos, Eric Deconinck, David Burns, Claude Eric Bulabois and 10 more

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Article in Bone marrow transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Guillaume DachyInstitut Roi Albert II, Cliniques Universitaires Saint-Luc, Brussels, Belgium. guillaumedachy89@gmail.com.ORCID 0000-0002-1668-975X
Myriam LabopinAcute Leukemia Working Party of the EBMT, Paris, France.ORCID 0000-0003-4514-4748
Gérard SociéSaint-Louis Hospital, BMT Unit, Paris, France.ORCID 0000-0002-2114-7533
Cristina Castilla-LlorenteGustave Roussy Cancer Campus, Villejuif, France.
Edouard ForcadeCHU Bordeaux, Hôpital Haut-Leveque, Pessac, France.ORCID 0000-0002-8873-2868
Igor Wolfgang BlauMedizinische Klinik mit Schwerpunkt Hämatologie, Onkologie und Tumorimmunologie, Berlin, Germany.
Patrice CeballosCHU Saint Eloi, Montpellier, France.
Eric DeconinckHopital Jean Minjoz, Besancon, France.ORCID 0000-0002-6006-8088
David BurnsBirmingham Centre for Cellular Therapy and Transplant (BCCTT), Birmingham, United Kingdom.
Claude Eric BulaboisCHU Grenoble Alpes - Université Grenoble Alpes, Grenoble, France.
Radovan VrhovacUniversity Hospital Center Zagreb, Zagreb, Croatia.ORCID 0000-0003-3323-3487
Anne HuynhInstitut Universitaire du Cancer de Toulouse - Oncopole, Toulouse, France.
Didier BlaiseInstitut Paoli Calmette, Programme de Transplantation & Therapie Cellulaire, Marseille, France.ORCID 0000-0002-5684-9447
Johan MaertensUniversity Hospital Gasthuisberg, Leuven, Belgium.ORCID 0000-0003-4257-5980
Thomas SchroederUniversity Hospital Essen, Essen, Germany.
Jacques-Olivier BayCHU Estaing, Clermont-Ferrand, France.ORCID 0000-0002-7032-5180
Bipin SavaniAcute Leukemia Working Party of the EBMT, Paris, France.ORCID 0000-0002-3304-9965
Alexandros SpyridonidisAcute Leukemia Working Party of the EBMT, Paris, France.ORCID 0000-0003-3097-2532
Fabio CiceriAcute Leukemia Working Party of the EBMT, Paris, France.ORCID 0000-0003-0873-0123
Mohamad MohtyAcute Leukemia Working Party of the EBMT, Paris, France.ORCID 0000-0002-7264-808X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the past decades, treatment for acute myeloid leukemia (AML) has advanced, but allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains vital for improving survival in most patients. This retrospective study, conducted on behalf of the Acute Leukemia Working Party of the EBMT, examines the impact of fludarabine dose in reduced-intensity conditioning regimens on clinical outcomes in patients over 50 years old with AML in first complete remission, without chronic kidney disease. We analyzed 1907 patients who underwent allo-HSCT between 2010 and 2022, stratifying them into four fludarabine dose groups: 110-130 mg/m

Indexed as

Hematopoietic Stem Cell TransplantationLeukemia, Myeloid, AcuteTransplantation ConditioningVidarabineAgedAllograftsDisease-Free SurvivalFemaleHumansMaleMiddle AgedRetrospective StudiesSurvival RateTransplantation, HomologousTreatment OutcomefludarabineVidarabine

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.