Evidence map›Paper›PMID 40537493›Full record

ArticleNPJ science of food2025

Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities.

Huixiang Wu, Miaoyu Li, Lijun Ge, Weibo Lu, Xuewei Shen, Yu Zhang, Zengyan Wu, Jianding Wang, Yonghui Wu, Huijuan Mao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Huixiang Wu *Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
Miaoyu Li *Collaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
Lijun GeCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
Weibo LuCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
Xuewei ShenCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
Yu ZhangCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
Zengyan WuDepartment of Gastroenterology, Linping Hospital of Integrated Traditional Chinese and Western Medicine, Hangzhou, China.
Jianding WangHangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, China.
Yonghui WuHangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, China.
Huijuan MaoHangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, China.
Jianliang ZhangHangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, China.
Qingcheng WangHangzhou Linping Hospital of Traditional Chinese Medicine, Hangzhou, China.
Jing XueCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China.
Qing ShenCollaborative Innovation Center of Seafood Deep Processing, Institute of Seafood, Zhejiang Gongshang University, Hangzhou, China. leonqshen@163.com.
Yuexing TuDepartment of Critical Care Medicine, Tongde Hospital of Zhejiang Province, Tongde Hospital of Zhejiang Province Afflicted to Zhejiang Chinese Medical University, Hangzhou, China. tuyuexing1988@163.com.

Funding

Jianding Wang 2023ZHA-KEB314Qingcheng Wang 2022KY1062Yuexing Tu GZY-ZJ-KJ-24008
6 · The paper itself

Abstract

Sea dragons (Syngnathus) are valuable marine resources with notable interspecific phenotypic similarities and variations in composition and efficacy. This study employed multi-omics technologies to comprehensively analyze and structurally identify the molecular components of six species of Syngnathus, effectively screening interspecific differential markers. Untargeted metabolomics revealed a total of 18 classes and 2264 metabolites, and lipids were found to be the principal differential metabolites. Lipidomics were utilized for in-depth lipid detection, expanding the original 412 lipids detected through metabolomics to 2078 lipids, among which 47 differential metabolites and 138 differential lipids were selected from multi-omics results. The integration of network pharmacology and molecular docking elucidated the multifactorial mechanisms by which Syngnathus exerts anti-sepsis effects, including modulation of inflammatory responses, and regulation of apoptosis, while identifying key targets such as IL6, STAT3, and MAPK14. This study suggests that they may have potential as natural sources for the development of anti-sepsis foods. Further studies on their bioavailability and in vitro and in vivo efficacy are required in the future.

Identifiers

PMID40537493
PMCPMC12179263

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.