ArticleNPJ biofilms and microbiomes2025
Tanzanian gut microbiota profiles linked to high but rapidly waning yellow fever antibody titers.
Article in NPJ biofilms and microbiomes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Distinct trajectories of urbanization shape the human gut microbiome across South Asia.Gut microbes · 2026Article
- Distinct trajectories of urbanization shape the human gut microbiome across South Asia.bioRxiv : the preprint server for biology · 2026Article
- Gut microbiota as a regulator of vaccine efficacy: implications for personalized vaccination.Gut microbes · 2025Review
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19 authors.
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Abstract
Vaccine responses vary across populations and are influenced by numerous intrinsic and extrinsic factors, including the gut microbiota. However, studies linking microbiota composition to vaccine immunogenicity in low- and middle-income countries are sparse. In this study, we examined the gut microbiota of 143 healthy rural and urban living Tanzanians who participated in a yellow fever vaccine (YF-17D) trial. We found significant differences in gut microbiota profiles between rural and urban participants. Rural-associated microbiota showed higher diversity and enrichment of taxa like Prevotella and Succinivibrio, which were linked to dietary intake patterns. Yellow fever neutralizing antibody titers were higher in rural compared to urban participants. Interestingly, a subset of urban individuals with a rural-like microbiota had higher antibody titers and faster antibody waning than those with a more industrialized microbiota. These findings suggest that gut microbiota composition might be linked to vaccine immunogenicity, potentially outweighing the influence of living location.
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