ArticleNeurology2025
Association of Superficial White Matter Microstructure With Cortical Pathology Deposition Across Early Stages of the AD Continuum.
Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Superficial white matter and gray matter jointly support cognition among older adults in India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability.Communications biology · 2026Article
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Free water changes and their correlations with multimodal biomarkers in frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Association between perivascular diffusion and white matter microstructural integrity, free water, Aβ burden, and cognition: diffusion tensor vs. kurtosis tensor.Frontiers in aging neuroscience · 2026Article
- A Multimodal Deep Learning Approach for White Matter Shape Prediction in Diffusion MRI Tractography.Human brain mapping · 2025Article
- The superficial white matter in language processing: Broca's area connections are bilaterally associated with individual performance in children and adults.bioRxiv : the preprint server for biology · 2025Article
- Mapping neurodegeneration with diffusion MRI: biomarkers, mechanisms, and clinical translation.Frontiers in neurologyReview
- Effects of diffusion MRI spatial resolution on human brain short-range association fiber reconstruction and structural connectivity estimation.Imaging neuroscience (Cambridge, Mass.)Article
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24 authors.
Funding
Abstract
BACKGROUND AND
objectivesβ-amyloid (Aβ) and tau, 2 prominent pathologies of Alzheimer disease (AD), originate in cortical regions and primarily affect, and even spread along, the white matter tracts directly connected to these cortical regions. Superficial white matter (SWM), containing short-range association connections beneath the cortex, has been affected in mild cognitive impairment and AD, with gaps in understanding the disease's early stages. We perform a detailed investigation of individual SWM connections with cortical pathology deposition and cognition in the early stages of the AD continuum.
methodsWe enroll participants with Aβ PET, tau PET, diffusion MRI, and cognitive status from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and Harvard Aging Brain Study (HABS). We stratify participants into disease stages following the Aβ/tau (AT) framework. We use diffusion MRI tractography to analyze SWM fiber clusters and assess their microstructure through free-water modeling, identifying significant differences between pathologically staged groups. We investigate associations of diffusion measures in SWM fiber clusters with regional pathology deposition (Aβ- and tau- PET uptake) and cognition.
resultsThe study includes 150 ADNI participants (mean age 73.6 years, 61.3% female) and 175 HABS participants (mean age 75.6 years, 61.1% female). We find the following: (1) SWM microstructure differs along the early-stage Alzheimer disease continuum, with primary abnormalities in posterior brain regions; (2) there are significant free-water alterations in cognitively intact but pathology-positive individuals ( DISCUSSION: The findings of this study suggest that the propagation of AD pathology and cognitive changes may involve SWM pathways even in the early stages, emphasizing the importance of SWM in developing AD therapies and early interventions.
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