Evidence map›Paper›PMID 40536887›Full record

ArticleJournal of cellular and molecular medicine2025

Insights From Amniotic and Umbilical Cord Mesenchymal Stem Cells in Wound Healing.

Nong-Er Shen, Yue Wu, Kaichuang Yang, Xiuling Xv, Gang Lu, Ruolang Pan, Yang Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nong-Er ShenDepartment of Pharmacy, Center for Clinical Pharmacy, Cancer Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Yue WuDepartment of Pharmacy, Center for Clinical Pharmacy, Cancer Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Kaichuang YangDepartment of Neurosurgery, Center for Rehabilitation Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Xiuling XvDepartment of Gynecology and Obstetrics, Hangzhou Hospital of Traditional Chinese Medicine, Affiliated Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Gang LuKey Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province, Institute for Cell-Based Drug Development of Zhejiang Province, Hangzhou, China.
Ruolang PanKey Laboratory of Cell-Based Drug and Applied Technology Development in Zhejiang Province, Institute for Cell-Based Drug Development of Zhejiang Province, Hangzhou, China.ORCID 0000-0002-0810-3392
Yang JinDepartment of Gynecology and Obstetrics, Hangzhou Hospital of Traditional Chinese Medicine, Affiliated Hangzhou TCM Hospital of Zhejiang Chinese Medical University, Hangzhou, China.

Funding

Zhejiang Provincial Natural Science Foundation of China LTGY23H090016
6 · The paper itself

Abstract

Skin repair is a complex physiological process that involves the coordinated actions of various cell types. This study examines the distinct roles of amniotic mesenchymal stem cells (A-MSCs) and umbilical cord mesenchymal stem cells (UC-MSCs) in skin healing using a mouse model. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses revealed significant differences in gene expression between A-MSCs and UC-MSCs. Specifically, A-MSCs exhibited upregulation of genes associated with extracellular matrix (ECM) organisation and cell migration, thereby enhancing their tissue remodelling capabilities. In contrast, UC-MSCs demonstrate increased expression of genes involved in angiogenesis and anti-inflammatory responses, highlighting their role in creating a favourable healing environment. These findings highlight the unique therapeutic potentials of A-MSCs and UC-MSCs in skin repair strategies. Although MSCs hold promise in regenerative medicine, challenges such as optimal cell selection and modulation of the inflammatory microenvironment remain to be addressed. Our research emphasises the need for continued research related to properties of MSCs to refine therapeutic approaches for effective wound healing.

Indexed as

AmnionMesenchymal Stem CellsUmbilical CordWound HealingAnimalsCell MovementExtracellular MatrixFemaleHumansMesenchymal Stem Cell TransplantationMiceSkinamniotic membraneinflammatory microenvironmentmesenchymal stem cellskin repairumbilical cord

Identifiers

PMID40536887
PMCPMC12178269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.