Evidence map›Paper›PMID 40536830›Full record

ArticleAddiction biology2025

The GPR88 Agonist RTI-122 Reduces Alcohol-Related Motivation and Consumption.

Dennis F Lovelock, Wen Liu, Sami Ben Hamida, Victoria L Cordero, Kalynn J Van Voorhies, Marion Martin, Isabella Guimaraes Olmo, Emmanuel Darcq, Md Toufiqur Rahman, Mickael Naassila and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Addiction biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dennis F LovelockBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Wen LiuBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sami Ben HamidaINSERM UMR 1247, University of Picardie Jules Verne, Amiens, France.
Victoria L CorderoBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Kalynn J Van VoorhiesBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Marion MartinINSERM UMR 1247, University of Picardie Jules Verne, Amiens, France.
Isabella Guimaraes OlmoINSERM UMR-S 1329, Strasbourg Translational Neuroscience and Psychiatry, University of Strasbourg, Strasbourg, France.
Emmanuel DarcqINSERM UMR-S 1329, Strasbourg Translational Neuroscience and Psychiatry, University of Strasbourg, Strasbourg, France.ORCID 0000-0002-8377-8015
Md Toufiqur RahmanCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina, USA.ORCID 0000-0003-2752-6822
Mickael NaassilaINSERM UMR 1247, University of Picardie Jules Verne, Amiens, France.ORCID 0000-0002-9788-0918
Brigitte L KiefferINSERM UMR-S 1329, Strasbourg Translational Neuroscience and Psychiatry, University of Strasbourg, Strasbourg, France.ORCID 0000-0002-8809-8334
Chunyang JinCenter for Drug Discovery, Research Triangle Institute, Research Triangle Park, North Carolina, USA.ORCID 0000-0001-6733-3094
Joyce BesheerBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID 0000-0001-6187-8376

Funding

The Role of Striosome Neurons in Mediating Opiod RewardP50DA005010 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WALWYN, WENDY M · 1987 to 2021
$30.7M
GPR88 Agonist for Alcoholism TreatmentR01AA026820 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI JIN, CHUNYANG, KIEFFER, BRIGITTE L. · 2018 to 2022
$2.4M
Morphine-responsive neurons of the medial habenula : a role in aversive states of morphine withdrawal ?R01DA048796 · NIDA · INSERM STRASBOURG · PI KIEFFER, BRIGITTE L. · 2020 to 2025
$1.4M
NIAAA NIH HHS R01 AA026820NIAAA NIH HHS R01AA026820NIDA NIH HHS P50 DA005010NIDA NIH HHS R01 DA048796
6 · The paper itself

Abstract

GPR88, an orphan G protein-coupled receptor primarily expressed in the striatum, has emerged as a potential target for treating alcohol use disorder (AUD) due to its role in modulating reward and motivational pathways. In this study, we investigated the effects of the GPR88 agonist RTI-122 on alcohol intake and motivation to self-administer alcohol under different conditions. In mice, RTI-122 reduced alcohol consumption in a two-bottle choice paradigm, which was prevented by Gpr88 knockout, confirming a GPR88-specific effect on the attenuation of alcohol drinking. In rats, RTI-122 dose-dependently reduced operant alcohol self-administration and decreased motivation to self-administer alcohol in progressive ratio tasks, regardless of whether the alcohol was adulterated with quinine or not. Additionally, a high dose of RTI-122 reduced yohimbine-induced reinstatement. Importantly, RTI-122 did not affect water intake in mice or sucrose self-administration in rats, indicating receptor- and reward-specific modulation of alcohol intake. These findings suggest that RTI-122, through GPR88 agonism, effectively reduces alcohol consumption and motivation across various contexts, positioning it as a promising lead for the development of new AUD treatments.

Indexed as

Alcohol DrinkingMotivationReceptors, G-Protein-CoupledAnimalsConditioning, OperantEthanolMaleMiceMice, Inbred C57BLMice, KnockoutQuinineRatsRewardSelf AdministrationYohimbineEthanolGpr88 protein, mouseQuinineReceptors, G-Protein-CoupledYohimbine

Identifiers

PMID40536830
PMCPMC12178211

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.